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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfkb1M3Btlr
mutation 3, Bruce Beutler
MGI:6113381
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nfkb1M3Btlr/Nfkb1M3Btlr C57BL/6J-Nfkb1M3Btlr MGI:6113383
ht2
 		Nfkb1M3Btlr/Nfkb1+ C57BL/6J-Nfkb1M3Btlr MGI:6113384


Genotype
MGI:6113383
hm1
Allelic
Composition		 Nfkb1M3Btlr/Nfkb1M3Btlr
Genetic
Background		 C57BL/6J-Nfkb1M3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1M3Btlr mutation (0 available); any Nfkb1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal humoral immune response ( J:254821 )
• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgG level ( J:254821 )
• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

digestive/alimentary system

hematopoietic system
decreased IgG level ( J:254821 )
• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)




Genotype
MGI:6113384
ht2
Allelic
Composition		 Nfkb1M3Btlr/Nfkb1+
Genetic
Background		 C57BL/6J-Nfkb1M3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1M3Btlr mutation (0 available); any Nfkb1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal humoral immune response ( J:254821 )
• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgG level ( J:254821 )
• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

hematopoietic system
decreased IgG level ( J:254821 )
• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory