Nfkb1^M3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nfkb1^M3Btlr
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; mutation 3, Bruce Beutler
• MGI ID: MGI:6113381
• Synonyms: Roomba
• Gene: Nfkb1 Location: Chr3:135290416-135397308 bp, - strand Genetic Position: Chr3, 62.82 cM
• Alliance: Nfkb1^M3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 135,612,412 (v38) on chromosome 3, corresponding to base pair 79,571 in the GenBank genomic region NC_000069 within the donor splice site of intron 12. The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation is predicted to result in skipping of the 139-nucleotide exon 12 (out of 25 total exons), resulting in a frame-shifted protein product beginning after amino acid 306 of the protein and premature termination after the inclusion of 80 aberrant amino acids. (J:254821)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkb1 Mutation: 99 strains or lines available

References

• Original: J:254821 Choi JH, et al., Mutagenetix entry for Roomba. MGI Direct Data Submission. 2018
• All: 1 reference(s)