Phenotypes associated with this allele

• Allele Symbol: Col1a1^{tm1(tetO-GFP/RNAi:Rad21)Iaai}
• Allele Name: targeted mutation 1, Iannis Aifantis
• Allele ID: MGI:5911564
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Col1a1^tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1^+ Gt(ROSA)26Sor^tm1(rtTA*M2)Jae/Gt(ROSA)26Sor^+	involves: 129S4/SvJae * C57BL/6	MGI:5911575

Genotype
MGI:5911575

cx1

• Allelic Composition: Col1a1^{tm1(tetO-GFP/RNAi:Rad21)Iaai}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:229031 )

• lineage skewing is seen following prolonged doxycycline exposure (30 days)

extramedullary hematopoiesis ( J:229031 )

• in the splenic parenchyma

abnormal bone marrow cell number ( J:229031 )

• decrease in the Ter119+ cell population

decreased B cell number ( J:229031 )

• decrease in the proportion of B cell population (B220+)

increased myeloid cell number ( J:229031 )

• increase in the proportion of myelomonocytic (Cd11b+/Gr1+) and erythroid (CD71+/Ter119+) cells

• increased amount of early erythroid (CD71+/Ter119+) cells in the spleen

abnormal hematopoietic stem cell morphology ( J:229031 )

• increase in nuclear size in sorted Lineage-/c-Kit+ progenitor cells not associated with an increase of genomic material or instability

increased hematopoietic stem cell number ( J:229031 )

• in the spleen

immune system

decreased B cell number ( J:229031 )

• decrease in the proportion of B cell population (B220+)