Col1a1^{tm1(tetO-GFP/RNAi:Rad21)Iaai}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1(tetO-GFP/RNAi:Rad21)Iaai}
• Name: collagen, type I, alpha 1; targeted mutation 1, Iannis Aifantis
• MGI ID: MGI:5911564
• Synonyms: Rad21^(shRNA)
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1(tetO-GFP/RNAi:Rad21)Iaai} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229031
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Knockdown, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Col1a1^{tm1(tetO-GFP/RNAi:Rad21)Iaai} involves 1 genes/genome features (Rad21) View all
• Mutation details: A construct containing a tetracycline promoter and a GFP fusion with a Mir30-based short hairpin sequence targeting Rad21 (Rad21-920) was inserted in the 3' UTR. (J:229031)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 166 strains or lines available

References

• Original: J:229031 Mullenders J, et al., Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms. J Exp Med. 2015 Oct 19;212(11):1833-50
• All: 1 reference(s)