All Phenotypes Ythdc2<em1Sky> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ythdc2^em1Sky/Ythdc2^em1Sky	involves: C57BL/6J * CBA	MGI:5911696
ht2	Ythdc2^em1Sky/Ythdc2^em3Sky	involves: C57BL/6J * CBA	MGI:8253261
ht3	Ythdc2^em1Sky/Ythdc2^ketu	involves: C57BL/6J * CBA * FVB/NJ	MGI:5911698

Allelic Composition	Ythdc2^em1Sky/Ythdc2^em1Sky
Genetic Background	involves: C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ythdc2^em1Sky mutation (0 available); any Ythdc2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

arrest of male meiosis ( J:256276 , J:324156 )

(J:256276)

• meiotic recombination is initiated but proceeds prematurely to an aberrant metaphase-like state; as a result, early prophase I stages (leptonema/zygonema) are depleted in juvenile and adult males (J:324156)

increased male germ cell apoptosis ( J:324156 )

small ovary ( J:256276 )

abnormal seminiferous tubule morphology ( J:324156 )

• at 9 weeks of age, seminiferous tubules with only a single layer of cells (spermatogonia plus Sertoli cells) are observed

• nearly empty tubules contain cells with abnormally condensed metaphase-like chromosomes

decreased testis weight ( J:256276 )

female infertility ( J:256276 )

male infertility ( J:256276 )

endocrine/exocrine glands

small ovary ( J:256276 )

abnormal seminiferous tubule morphology ( J:324156 )

• at 9 weeks of age, seminiferous tubules with only a single layer of cells (spermatogonia plus Sertoli cells) are observed

• nearly empty tubules contain cells with abnormally condensed metaphase-like chromosomes

decreased testis weight ( J:256276 )

cellular

arrest of male meiosis ( J:256276 , J:324156 )

(J:256276)

increased male germ cell apoptosis ( J:324156 )

homeostasis/metabolism

abnormal metabolism ( J:324156 )

• whole-testis ribosome profiling assays show no significant change in the translation efficiency of YTHDC2 mRNA binding targets during meiotic entry, irrespective of whether they are bound by YTHDC2 in the CDS or 3 UTR; however, at 10 dpp, transcript levels of top YTHDC2 3 UTR targets are modestly but significantly increased

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased elongated spermatid number ( J:324156 )

• seminiferous tubules lack postmeiotic elongated spermatids at 9 weeks of age

decreased round spermatid number ( J:324156 )

• seminiferous tubules lack postmeiotic round spermatids at 9 weeks of age

arrest of male meiosis ( J:324156 )

• meiotic progression is arrested during late pachynema

• no cells containing abnormally condensed metaphase-like chromosomes are detected and pH3-positive luminally located metaphase cells are absent or extremely rare

increased male germ cell apoptosis ( J:324156 )

• TUNEL staining shows a significant increase in the % of tubules containing 10 or more apoptotic cells at 8-9 weeks of age

abnormal seminiferous tubule morphology ( J:324156 )

• adult seminiferous tubules are devoid of postmeiotic cells

• largely empty tubules containing early spermatogenic cells and cells with compacted apoptotic-like nuclei are present alongside tubules containing meiotic spermatocytes, suggesting that cells can progress into prophase I but likely arrest after meiotic entry

• fewer tubules contain a single pachytene layer (47%-51% vs 86%92% in wild-type with an additional spermatid layer) and no tubules contain one layer of late pachynema/diplonema plus a layer in leptonema/zygonema (0% vs 8%-14% in wild-type with an additional spermatid layer)

decreased testis weight ( J:324156 )

• adult testis weight-to-body weight ratios are 33.4% smaller than in littermate controls

female infertility ( J:324156 )

• none of 4 females paired with wild-type males for 13 weeks led to pregnancies or birth of offspring

male infertility ( J:324156 )

• none of 3 males paired with wild-type females for 5 weeks led to pregnancies or birth of offspring

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:324156 )

• adult seminiferous tubules are devoid of postmeiotic cells

decreased testis weight ( J:324156 )

• adult testis weight-to-body weight ratios are 33.4% smaller than in littermate controls

cellular

decreased elongated spermatid number ( J:324156 )

• seminiferous tubules lack postmeiotic elongated spermatids at 9 weeks of age

decreased round spermatid number ( J:324156 )

• seminiferous tubules lack postmeiotic round spermatids at 9 weeks of age

arrest of male meiosis ( J:324156 )

• meiotic progression is arrested during late pachynema

• no cells containing abnormally condensed metaphase-like chromosomes are detected and pH3-positive luminally located metaphase cells are absent or extremely rare

increased male germ cell apoptosis ( J:324156 )

• TUNEL staining shows a significant increase in the % of tubules containing 10 or more apoptotic cells at 8-9 weeks of age

Allelic Composition	Ythdc2^em1Sky/Ythdc2^ketu
Genetic Background	involves: C57BL/6J * CBA * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ythdc2^em1Sky mutation (0 available); any Ythdc2 mutation (58 available)
Ythdc2^ketu mutation (0 available); any Ythdc2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased testis weight ( J:256276 )

male infertility ( J:256276 )

endocrine/exocrine glands

decreased testis weight ( J:256276 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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