About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ergtm1.1Iwamo
targeted mutation 1.1, Masahiro Iwamoto
MGI:5910506
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ergtm1.1Iwamo/Ergtm1.1Iwamo
Tg(Gdf5-cre,-ALPP)1Kng/?
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:5910547


Genotype
MGI:5910547
cn1
Allelic
Composition
Ergtm1.1Iwamo/Ergtm1.1Iwamo
Tg(Gdf5-cre,-ALPP)1Kng/?
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ergtm1.1Iwamo mutation (1 available); any Erg mutation (27 available)
Tg(Gdf5-cre,-ALPP)1Kng mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• 8 week old mice are more susceptible to surgically induced osteoarthritis in knees than controls
• 4 weeks post-surgery articular cartilage is eroded and the region develops ectopic chondrocyte hypertrophy and is lacking Safranin O-staining proteoglycans and lubricin
• knee articular cartilage is thin, eroded and almost absent in joints of 6-7 month old mice
• tibial plateau exhibits arthritic changes based on osteoarthritis assessment criteria
• knee joint surface of the femur exhibits arthritic changes based on osteoarthritis assessment criteria
• knee articular cartilage is thin, eroded and almost absent in joints of 6-7 month old mice

immune system
• 8 week old mice are more susceptible to surgically induced osteoarthritis in knees than controls
• 4 weeks post-surgery articular cartilage is eroded and the region develops ectopic chondrocyte hypertrophy and is lacking Safranin O-staining proteoglycans and lubricin
• knee articular cartilage is thin, eroded and almost absent in joints of 6-7 month old mice
• tibial plateau exhibits arthritic changes based on osteoarthritis assessment criteria
• knee joint surface of the femur exhibits arthritic changes based on osteoarthritis assessment criteria

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteoarthritis DOID:8398 J:243715





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
06/12/2024
MGI 6.13
The Jackson Laboratory