All Phenotypes Srebf2<tm1Jdh> MGI Mouse

growth/size/body

decreased body weight ( J:241873 )

• mice weigh less than controls, however liver weights are unchanged

homeostasis/metabolism

abnormal lipid homeostasis ( J:241873 )

• rate of sterol synthesis in the liver is decreased by 59%

• rate of fatty acid synthesis in the liver is decreased by 68%

• plasma cholesterol level is reduced by 68%

• plasma triglyceride level is reduced by 50%

decreased liver cholesterol level ( J:241873 )

• liver cholesterol level is reduced by 20%

• dietary supplementation with 0.2% cholesterol increased liver cholesterol concentrations to control levels

• liver triglyceride level is reduced by 76%

• triglyceride secretion rate from liver is reduced by 29%

liver/biliary system

decreased liver cholesterol level ( J:241873 )

• liver cholesterol level is reduced by 20%

• dietary supplementation with 0.2% cholesterol increased liver cholesterol concentrations to control levels

• liver triglyceride level is reduced by 76%

• triglyceride secretion rate from liver is reduced by 29%

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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