All Phenotypes Gt(ROSA)26Sor<tm11(CAG-tdTomato*,-GFP*)Nat> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm11(CAG-tdTomato*,-GFP*)Nat}
targeted mutation 11, Jeremy Nathans
MGI:5904987

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm11(CAG-tdTomato,-GFP)Nat}/? Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(Myh6-cre)2182Mds/0	involves: 129 * C57BL/6 * FVB/N	MGI:8226709
cn2	Gt(ROSA)26Sor^{tm11(CAG-tdTomato,-GFP)Nat}/? Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(myl7.L-cre)1118Tmhn/0	involves: 129 * C57BL/6 * MF1	MGI:8226708

Allelic Composition	Gt(ROSA)26Sor^{tm11(CAG-tdTomato,-GFP)Nat}/? Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm11(CAG-tdTomato*,-GFP*)Nat} mutation (1 available); any Gt(ROSA)26Sor mutation (1031 available)
Rbpms2^tm2.1Thbr mutation (0 available); any Rbpms2 mutation (202 available)
Rbpms^tm1.1Thbr mutation (0 available); any Rbpms mutation (493 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal fetal cardiomyocyte morphology ( J:369747 )

• at E16.5 the nuclei are irregular in outline and size or associated with micronuclei

increased fetal cardiomyocyte apoptosis ( J:369747 )

• at E18.5

muscle

increased fetal cardiomyocyte apoptosis ( J:369747 )

• at E18.5

cellular

increased fetal cardiomyocyte apoptosis ( J:369747 )

• at E18.5

abnormal cell nucleus morphology ( J:369747 )

• at E16.5 the nuclei of cardiomyocytes are irregular in outline and size or associated with micronuclei

increased micronucleus incidence ( J:369747 )

• at E16.5 the nuclei of cardiomyocytes are irregular in outline and size or associated with micronuclei

Allelic Composition	Gt(ROSA)26Sor^{tm11(CAG-tdTomato,-GFP)Nat}/? Rbpms^tm1.1Thbr/Rbpms^tm1.1Thbr Rbpms2^tm2.1Thbr/Rbpms2^tm2.1Thbr Tg(myl7.L-cre)1118Tmhn/0
Genetic Background	involves: 129 * C57BL/6 * MF1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal fetal cardiomyocyte morphology ( J:369747 )

• at E12.5 the nuclei are irregular in outline and size or associated with micronuclei

cellular

abnormal cell nucleus morphology ( J:369747 )

• at E12.5 the nuclei of cardiomyocytes are irregular in outline and size or associated with micronuclei

increased micronucleus incidence ( J:369747 )

• at E12.5 the nuclei of cardiomyocytes are irregular in outline and size or associated with micronuclei

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