Phenotypes associated with this allele

• Allele Symbol: Polr1d^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5904258
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polr1d^em1(IMPC)J/Polr1d^em1(IMPC)J	C57BL/6NJ-Polr1d^em1(IMPC)J/Mmjax	MGI:6288658
ht2	Polr1d^em1(IMPC)J/Polr1d^+	C57BL/6NJ-Polr1d^em1(IMPC)J/Mmjax	MGI:7451461

Genotype
MGI:6288658

hm1

• Allelic Composition: Polr1d^em1(IMPC)J/Polr1d^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Polr1d^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Polr1d

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cell death ( J:279207 )

• embryos show no further development with apparent cell death after 3 days in culture

embryo

failure of blastocyst formation ( J:279207 )

• embryos fail to reach a morphological blastocyst stage after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in culture, embryos fail to hatch from the zona pellucida with apparent cell death, never reaching a morphological blastocyst stage

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos appearing as compacted morulas are recovered at expected Mendelian ratios at E3.5 but arrest/die prior to blastocyst formation; no embryos or excess resorption sites are observed at E7.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:7451461

ht2

• Allelic Composition: Polr1d^em1(IMPC)J/Polr1d⁺
• Genetic Background: C57BL/6NJ-Polr1d^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Polr1d

homeostasis/metabolism

increased circulating aspartate transaminase level ( J:211773 )

♂

IMPC - JAX