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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k3tm1.1Mlkn
targeted mutation 1.1, Mark Kahn
MGI:5882560
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ccm2tm1Mlkn/Ccm2tm1Mlkn
Map3k3tm1.1Mlkn/Map3k3+
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: 129 * C57BL/6NTac MGI:6279213
cn2
 		Krit1tm1Kwhi/Krit1tm1Kwhi
Map3k3tm1.1Mlkn/Map3k3+
Nfatc1tm1.1(cre)Bz/Nfatc1+ 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl * C57BL/6NTac MGI:6279292
cn3
 		Map3k3tm1.1Mlkn/Map3k3tm1.2Mlkn
Nfatc1tm1.1(cre)Bz/Nfatc1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac MGI:6279295
cn4
 		Krit1tm1Kwhi/Krit1tm1Kwhi
Map3k3tm1.1Mlkn/Map3k3+
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: 129S6/SvEvTac * C57BL/6NCrl * C57BL/6NTac MGI:6279215


Genotype
MGI:6279213
cn1
Allelic
Composition		 Ccm2tm1Mlkn/Ccm2tm1Mlkn
Map3k3tm1.1Mlkn/Map3k3+
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: 129 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2tm1Mlkn mutation (0 available); any Ccm2 mutation (47 available)
Map3k3tm1.1Mlkn mutation (0 available); any Map3k3 mutation (24 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:232707 , J:250906 )
N
• tamoxifen injected mice show full rescue of cerebral cavernous malformation lesion formation (J:232707)
• tamoxifen injected mice do not exhibit cerebral cavernous malformation lesions (J:250906)




Genotype
MGI:6279292
cn2
Allelic
Composition		 Krit1tm1Kwhi/Krit1tm1Kwhi
Map3k3tm1.1Mlkn/Map3k3+
Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krit1tm1Kwhi mutation (0 available); any Krit1 mutation (34 available)
Map3k3tm1.1Mlkn mutation (0 available); any Map3k3 mutation (24 available)
Nfatc1tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased cardiac jelly amount ( J:238897 )
• area occupied by cardiac jelly in the trabeculae is decreased only 25% at E10.5, indicating some rescue of cardiac jelly




Genotype
MGI:6279295
cn3
Allelic
Composition		 Map3k3tm1.1Mlkn/Map3k3tm1.2Mlkn
Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k3tm1.1Mlkn mutation (0 available); any Map3k3 mutation (24 available)
Map3k3tm1.2Mlkn mutation (0 available); any Map3k3 mutation (24 available)
Nfatc1tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis ( J:238897 )
• embryonic lethality prior to E12.5

cardiovascular system
thin myocardium ( J:238897 )
• thin myocardial cell layer
• however, cardiac jelly is preserved and endocardial-myocardial separation at E10.5 is normal

muscle
thin myocardium ( J:238897 )
• thin myocardial cell layer
• however, cardiac jelly is preserved and endocardial-myocardial separation at E10.5 is normal




Genotype
MGI:6279215
cn4
Allelic
Composition		 Krit1tm1Kwhi/Krit1tm1Kwhi
Map3k3tm1.1Mlkn/Map3k3+
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrl * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krit1tm1Kwhi mutation (0 available); any Krit1 mutation (34 available)
Map3k3tm1.1Mlkn mutation (0 available); any Map3k3 mutation (24 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:232707 )
N
• tamoxifen injected mice show a reduction in the number and size of vascular lesions in the brain at P11, with nearly complete prevention of lesions




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory