Analysis Tools
mortality/aging
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• although present at normal Mendelian ratios at birth, no homozygotes are recovered at P5-P10
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craniofacial
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• styloid process hypoplasia at P0
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• 7 of 14 newborn homozygotes exhibit hypoplastic middle ear bones with variable expressivity
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• incus hypoplasia at P0
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• at P0
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• stapes hypoplasia at P0
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• second pharyngeal arches are hypoplastic at E9.5
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cleft palate
(
J:226497
)
|
• 11 of 16 newborn homozygotes exhibit cleft palate
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limbs/digits/tail
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• all (16 of 16) newborn homozygotes exhibit postaxial polydactyly with variable expressivity
• extra digit in least severely affected mice consists of only soft tissue without cartilage or bone elements
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skeleton
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• styloid process hypoplasia at P0
|
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• 7 of 14 newborn homozygotes exhibit hypoplastic middle ear bones with variable expressivity
|
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• incus hypoplasia at P0
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• at P0
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• stapes hypoplasia at P0
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• newborn homozygotes exhibit an additional thoracic (T14) vertebra
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• newborn homozygotes exhibit an L1 to T14 transformation with small ribs growing from T14
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embryo
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• second pharyngeal arches are hypoplastic at E9.5
|
hearing/vestibular/ear
|
• 7 of 14 newborn homozygotes exhibit hypoplastic middle ear bones with variable expressivity
|
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• incus hypoplasia at P0
|
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• at P0
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• stapes hypoplasia at P0
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• tympanic ring hypoplasia at P0
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growth/size/body
cleft palate
(
J:226497
)
|
• 11 of 16 newborn homozygotes exhibit cleft palate
|
digestive/alimentary system
cleft palate
(
J:226497
)
|
• 11 of 16 newborn homozygotes exhibit cleft palate
|
