All Phenotypes Cpt2<tm1Mwol> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cpt2^tm1Mwol
targeted mutation 1, Michael J Wolfgang
MGI:5819280

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cpt2^tm1Mwol/Cpt2^tm1Mwol Rab30^em1Mwol/Rab30^em1Mwol Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * DBA	MGI:8210461
cn2	Cpt2^tm1Mwol/Cpt2^tm1Mwol Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * DBA	MGI:7407341

Allelic Composition	Cpt2^tm1Mwol/Cpt2^tm1Mwol Rab30^em1Mwol/Rab30^em1Mwol Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpt2^tm1Mwol mutation (0 available); any Cpt2 mutation (28 available)
Rab30^em1Mwol mutation (0 available); any Rab30 mutation (16 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:348980 )

N	• unlike in fasted mice with liver specific loss of Cpt2 alone, double knockout mice have a reversal of the increase in triglycerides and cholesterol levels back to control levels

decreased circulating glucose level ( J:348980 )

• in fasted females compared to controls

decreased circulating ketone body level ( J:348980 )

• decrease in fasting ketone bodies

increased circulating free fatty acids level ( J:348980 )

• compared to fasted controls and fasted mice with hepatic specific loss of Cpt2 only

• differences are not seen in the fed state

increased liver triglyceride level ( J:348980 )

liver/biliary system

enlarged liver ( J:348980 )

• larger and paler in fasted mice

increased liver triglyceride level ( J:348980 )

abnormal hepatocyte morphology ( J:348980 )

• in fasted mice hepatocytes appear swollen and lipid laden

hepatic steatosis ( J:348980 )

• fasting induced lipid accumulation

pale liver ( J:348980 )

• in fasted mice

growth/size/body

enlarged liver ( J:348980 )

• larger and paler in fasted mice

Allelic Composition	Cpt2^tm1Mwol/Cpt2^tm1Mwol Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpt2^tm1Mwol mutation (0 available); any Cpt2 mutation (28 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating ketone body level ( J:348980 )

• decrease in fasting ketone bodies

increased circulating cholesterol level ( J:348980 )

• in fasted mice

increased circulating triglyceride level ( J:348980 )

• in fasted mice

increased liver triglyceride level ( J:348980 )

• in fasted mice

liver/biliary system

enlarged liver ( J:348980 )

• larger and paler in fasted mice

increased liver triglyceride level ( J:348980 )

• in fasted mice

abnormal hepatocyte morphology ( J:348980 )

• in fasted mice hepatocytes appear swollen and lipid laden

hepatic steatosis ( J:348980 )

• fasting induced lipid accumulation

pale liver ( J:348980 )

• in fasted mice

growth/size/body

enlarged liver ( J:348980 )

• larger and paler in fasted mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24