All Phenotypes Cpt2<tm1Mwol> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cpt2^tm1Mwol
targeted mutation 1, Michael J Wolfgang
MGI:5819280

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cpt2^tm1Mwol/Cpt2^tm1Mwol Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * DBA	MGI:7407341
cn2	Cpt2^tm1Mwol/Cpt2^tm1Mwol Rab30^em1Mwol/Rab30^em1Mwol Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * DBA	MGI:8210461

Allelic Composition	Cpt2^tm1Mwol/Cpt2^tm1Mwol Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpt2^tm1Mwol mutation (0 available); any Cpt2 mutation (28 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating ketone body level ( J:348980 )

• decrease in fasting ketone bodies

increased circulating cholesterol level ( J:348980 )

• in fasted mice

increased circulating triglyceride level ( J:348980 )

• in fasted mice

increased liver triglyceride level ( J:348980 )

• in fasted mice

liver/biliary system

enlarged liver ( J:348980 )

• larger and paler in fasted mice

increased liver triglyceride level ( J:348980 )

• in fasted mice

abnormal hepatocyte morphology ( J:348980 )

• in fasted mice hepatocytes appear swollen and lipid laden

hepatic steatosis ( J:348980 )

• fasting induced lipid accumulation

pale liver ( J:348980 )

• in fasted mice

growth/size/body

enlarged liver ( J:348980 )

• larger and paler in fasted mice

Allelic Composition	Cpt2^tm1Mwol/Cpt2^tm1Mwol Rab30^em1Mwol/Rab30^em1Mwol Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpt2^tm1Mwol mutation (0 available); any Cpt2 mutation (28 available)
Rab30^em1Mwol mutation (0 available); any Rab30 mutation (16 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:348980 )

N	• unlike in fasted mice with liver specific loss of Cpt2 alone, double knockout mice have a reversal of the increase in triglycerides and cholesterol levels back to control levels

decreased circulating glucose level ( J:348980 )

• in fasted females compared to controls

decreased circulating ketone body level ( J:348980 )

• decrease in fasting ketone bodies

increased circulating free fatty acids level ( J:348980 )

• compared to fasted controls and fasted mice with hepatic specific loss of Cpt2 only

• differences are not seen in the fed state

increased liver triglyceride level ( J:348980 )

liver/biliary system

enlarged liver ( J:348980 )

• larger and paler in fasted mice

increased liver triglyceride level ( J:348980 )

abnormal hepatocyte morphology ( J:348980 )

• in fasted mice hepatocytes appear swollen and lipid laden

hepatic steatosis ( J:348980 )

• fasting induced lipid accumulation

pale liver ( J:348980 )

• in fasted mice

growth/size/body

enlarged liver ( J:348980 )

• larger and paler in fasted mice

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