All Phenotypes Hlcs<em1(IMPC)J> MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

failure to gastrulate ( J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

IMPC - JAX (J:211773)

MGI

• homozygous embryos are recovered at expected Mendelian ratios at E7.5 but arrest prior to gastrulation (J:279207)

• no homozygous embryos are recovered at E9.5

IMPC - JAX

Allelic Composition	Hlcs^em1(IMPC)J/Hlcs⁺
Genetic Background	C57BL/6NJ-Hlcs^em1(IMPC)J/Mmjax

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hlcs^em1(IMPC)J mutation (2 available); any Hlcs mutation (43 available)

Data Sources

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

IMPC - JAX

IMPC - JAX

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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