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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Olfm4tm2.1(EGFP/cre/ERT2)Cle
targeted mutation 2.1, Hans Clevers
MGI:5805245
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Olfm4tm2.1(EGFP/cre/ERT2)Cle/Olfm4+ involves: 129P2/OlaHsd * C57BL/6 MGI:6401287
cn2
 		Olfm4tm2.1(EGFP/cre/ERT2)Cle/Olfm4+
Znhit1tm1.1Nju/Znhit1tm1.1Nju 		involves: 129P2/OlaHsd * C57BL/6 MGI:6360246


Genotype
MGI:6401287
ht1
Allelic
Composition		 Olfm4tm2.1(EGFP/cre/ERT2)Cle/Olfm4+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olfm4tm2.1(EGFP/cre/ERT2)Cle mutation (0 available); any Olfm4 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:285672 )
• mice exhibit normal intestinal morphology and physiology under basal conditions and normal response to irradiation
abnormal intestinal epithelium physiology ( J:285672 )
• intestinal stem cells treated with tamoxifen exhibit impaired organoid formation compared with control cells




Genotype
MGI:6360246
cn2
Allelic
Composition		 Olfm4tm2.1(EGFP/cre/ERT2)Cle/Olfm4+
Znhit1tm1.1Nju/Znhit1tm1.1Nju
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olfm4tm2.1(EGFP/cre/ERT2)Cle mutation (0 available); any Olfm4 mutation (32 available)
Znhit1tm1.1Nju mutation (0 available); any Znhit1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:276456 )
• all mice die by 18 days post tamoxifen treatment

digestive/alimentary system
abnormal intestine development ( J:276456 )
• postnatal depletion of intestinal stem cells in tamoxifen-treated mice
• however, embryonic development of Lgr5+ progenitor cells is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory