Znhit1^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Znhit1^tm1.1Nju
• Name: zinc finger, HIT domain containing 1; targeted mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6360223
• Synonyms: Znhit1^fl
• Gene: Znhit1 Location: Chr5:137011048-137016813 bp, - strand Genetic Position: Chr5, 76.09 cM, cytoband G1
• Alliance: Znhit1^tm1.1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276456
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3, An FRT-flanked neomycin resistance cassette with a 3'loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the selection cassette. (J:276456)

Expression

In Mice Carrying this Mutation:	225 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Znhit1 Mutation: 16 strains or lines available

References

• Original: J:276456 Zhao B, et al., Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation. Nat Commun. 2019 Mar 6;10(1):1071
• All: 6 reference(s)