Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Bglap2-TAg)1Rkho mutation
(0 available)
Tg(Col1a1-cre)1Kry mutation
(2 available)
Tnfrsf11atm1.1Pngr mutation
(0 available);
any
Tnfrsf11a mutation
(42 available)
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neoplasm
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• tumor onset, survival, tumor burden, and lung metastasis is comparable to single Tg(Bglap2-TAg)1Rkho hemizygous mice
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skeleton
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• tumor onset, survival, tumor burden, and lung metastasis is comparable to single Tg(Bglap2-TAg)1Rkho hemizygous mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm1.2Lsk mutation
(1 available);
any
Prkar1a mutation
(19 available)
Tg(Bglap2-TAg)1Rkho mutation
(0 available)
Tg(Col1a1-cre)1Kry mutation
(2 available)
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Prkar1a heterozygosity accelerates osteosarcoma development in Tg(Bglap2-TAg)1Rkho/0 mice
mortality/aging
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• no mice survive past 5 weeks of age
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neoplasm
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• mice develop advanced osteosarcoma, often in the spine
• mice exhibit multi-ostotic tumors in long and flat bones, including the skull, vertebrae, ribs, and tibia
• however, metastasis is not seen at this early age
• tumors show increased osteoclast numbers
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skeleton
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• mice develop advanced osteosarcoma, often in the spine
• mice exhibit multi-ostotic tumors in long and flat bones, including the skull, vertebrae, ribs, and tibia
• however, metastasis is not seen at this early age
• tumors show increased osteoclast numbers
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behavior/neurological
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• impaired mobility due to osteosarcoma in the spine
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• paralysis due to osteosarcoma in the spine
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Bglap2-TAg)1Rkho mutation
(0 available)
Tnfsf11tm1Pngr mutation
(0 available);
any
Tnfsf11 mutation
(30 available)
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neoplasm
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• mice exhibit suppression of osteosarcoma development with only 2 of 35 mice showing tumors
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limbs/digits/tail
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• femurs from 42 week old mice show only benign parosteal growths without evidence of malignant cells
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skeleton
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• femurs from 42 week old mice show only benign parosteal growths without evidence of malignant cells
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• mice exhibit suppression of osteosarcoma development with only 2 of 35 mice showing tumors
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Bglap2-TAg)1Rkho mutation
(0 available)
Tnfsf11tm1Pngr mutation
(0 available);
any
Tnfsf11 mutation
(30 available)
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neoplasm
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• mice exhibit the same tumor incidence, burden and survival as single Tg(Bglap2-TAg)1Rkho hemizygous mice
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skeleton
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• mice exhibit the same tumor incidence, burden and survival as single Tg(Bglap2-TAg)1Rkho hemizygous mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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Poorly calcified femur tumor with bone destruction in a Tg(Bglap2-TAg)1Rkho/0 mouse
mortality/aging
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• mice die after 21 weeks of age due to tumors
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neoplasm
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• spontaneous metastases are seen in the lungs of more than 90% of mice at time of morbidity, and less frequently in the liver and occasionally in the kidney and spleen
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• mice form multi-ostotic bone tumors with complete penetrance at a young age and showing varying levels of calcification
• skeletal tumors show a peak incidence in the long bones and a higher prevalence of craniofacial tumors
• tumors exhibit increased osteoclast numbers
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• mice develop a spectrum of osteoblastic lesions from benign osteoma to aggressive metastatic osteosarcoma, with most being osteoblastic osteosarcoma, with features typical of high-grade osteosarcoma
• osteosarcomas are genomically unstable
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skeleton
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• mice form multi-ostotic bone tumors with complete penetrance at a young age and showing varying levels of calcification
• skeletal tumors show a peak incidence in the long bones and a higher prevalence of craniofacial tumors
• tumors exhibit increased osteoclast numbers
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• mice develop a spectrum of osteoblastic lesions from benign osteoma to aggressive metastatic osteosarcoma, with most being osteoblastic osteosarcoma, with features typical of high-grade osteosarcoma
• osteosarcomas are genomically unstable
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• 50% of mice survive to 26 weeks of age
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neoplasm
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• mice develop aggressive osteosarcoma with complete penetrance
• treatment of mice with RANK-Fc beginning at 17 weeks of age suppresses osteosarcoma progression and reduces lung metastasis by more than 3-fold
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skeleton
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• mice develop aggressive osteosarcoma with complete penetrance
• treatment of mice with RANK-Fc beginning at 17 weeks of age suppresses osteosarcoma progression and reduces lung metastasis by more than 3-fold
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Analysis Tools