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| Caption | Full-body skeleton CT scans of 3-to-4-week-old (D) Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 Tg(Bglap2-TAg)1Rkho/0 (Prkar1adeltaOB/+/MOTO+), (E) Tg(Bglap2-TAg)1Rkho/0 (MOTO+), and (F) Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 (Prkar1adeltaOB/+) mice. Tumor-bearing bones of Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 Tg(Bglap2-TAg)1Rkho/0 mouse in D are shown at higher magnification in middle panels (skull, humerus, scapula, rib, spine, and femur/tibia), with matching maximum intensity projections shown in bottom panels. (G) Radiograph of tibia of a 12-week-old mouse with abnormal growths (punctate densities), with corresponding H&E-stained sections (H) showing benign osteomas. Scale bars: 1 mm (top); 150 um (middle); 50 um (bottom). (I) Micro-CT images of femurs in 6- to 18-week-old mice. Images through the sagittal plane (top) reveal anomalous thickening of trabeculae and/or cortex (arrowheads) at 6 weeks of age and progressively more radiodense regions (arrowheads) at 12 and 18 weeks. 3D reconstructions of 18-week-old WT and MOTO (right) femurs show a parosteal tumor (arrow) with destroyed underlying cortex. Arrows indicate lesions throughout. | ||||||||
| Copyright | This image is from Molyneux SD, J Clin Invest 2010 Sep 1;120(9):3310-25 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:165282 | ||||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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