All Phenotypes Pnkp<tm1.1Pmc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pnkp^tm1.1Pmc
targeted mutation 1.1, Peter J McKinnon
MGI:5795744

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S1/Sv * 129S2/SvPas * C57BL/6	MGI:5795755
cn2	Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S1/Sv * C57BL/6 * CBA	MGI:5795747
cn3	Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S1/Sv * C57BL/6 * CBA	MGI:5795834
cn4	Atm^tm2Pmc/Atm^tm2Pmc Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Tg(Nes-cre)1Kln/0	involves: 129S1/Sv * C57BL/6 * SJL	MGI:5795758
cn5	Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Tg(Nes-cre)1Kln/0	involves: 129S1/Sv * C57BL/6 * SJL	MGI:5795748

Allelic Composition	Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (30 available)
Pnkp^tm1.1Pmc mutation (0 available); any Pnkp mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased brain apoptosis ( J:226703 )

• loss of all dorsal telencephalic progenitors via apoptosis

decreased cell proliferation ( J:226703 )

• proliferation in the cortex is reduced by E15.5 compared with E13.5

growth/size/body

decreased body size ( J:226703 )

• body size is reduced at P5

nervous system

increased brain apoptosis ( J:226703 )

• loss of all dorsal telencephalic progenitors via apoptosis

decreased brain size ( J:226703 )

• brain size is reduced at P5

abnormal cerebellar cortex morphology ( J:226703 )

• almost complete absence of the cortex

Allelic Composition	Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (44 available)
Pnkp^tm1.1Pmc mutation (0 available); any Pnkp mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:226703 )

• early lethality, with no embryos recovered after E9

Allelic Composition	Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnkp^tm1.1Pmc mutation (0 available); any Pnkp mutation (36 available)
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased oligodendrocyte number ( J:226703 )

• mice treated with tamoxifen at P21 (3 doses every 2 days) exhibit a decrease in oligodendrocyte numbers in the dentate gyrus but not in the cortex at P33

increased brain apoptosis ( J:226703 )

• mice treated with tamoxifen at P10 (3 doses every 2 days) exhibit apoptosis in the dentate gyrus at P20

growth/size/body

decreased body size ( J:226703 )

• mice treated with tamoxifen at P7 exhibit a decreased body size at P13

• mice treated with tamoxifen at P10 (3 doses every 2 days) exhibit a modest effect on brain size at P20

nervous system

decreased oligodendrocyte number ( J:226703 )

• mice treated with tamoxifen at P21 (3 doses every 2 days) exhibit a decrease in oligodendrocyte numbers in the dentate gyrus but not in the cortex at P33

increased brain apoptosis ( J:226703 )

• mice treated with tamoxifen at P10 (3 doses every 2 days) exhibit apoptosis in the dentate gyrus at P20

decreased brain size ( J:226703 )

• mice treated with tamoxifen at P7 exhibit decreased brain size

• however, mice treated with tamoxifen at P21 (3 doses every 2 days) exhibit little overall effect on brain size or structure

abnormal cerebellar cortex morphology ( J:226703 )

• mice treated with tamoxifen at P7 exhibit a reduction in cortical size

decreased neuron number ( J:226703 )

• mice treated with tamoxifen at P21 show a reduction of mature neurons in the dentate gyrus, the hippocampal CA3 region and the cerebellum

abnormal myelination ( J:226703 )

• myelin-producing oligodendrocytes from mice treated with tamoxifen at P21 show a reduction in myelination

• mice treated with tamoxifen at P10 (3 doses every 2 days) exhibit a loss of myelination in the dentate gyrus at P20

• mice treated with tamoxifen at P14 (3 doses every 2 days) exhibit a loss of myelination of oligodendrocytes at P30

Allelic Composition	Atm^tm2Pmc/Atm^tm2Pmc Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm2Pmc mutation (0 available); any Atm mutation (168 available)
Pnkp^tm1.1Pmc mutation (0 available); any Pnkp mutation (36 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

intracranial hemorrhage ( J:226703 )

• hemorrhage in the brain

cellular

increased brain apoptosis ( J:226703 )

• apoptosis in the developing cerebellum is similar to single conditional Pnkp mutants

nervous system

intracranial hemorrhage ( J:226703 )

• hemorrhage in the brain

increased brain apoptosis ( J:226703 )

• apoptosis in the developing cerebellum is similar to single conditional Pnkp mutants

abnormal brain interneuron morphology ( J:226703 )

• reduction in cerebellar interneurons

Allelic Composition	Pnkp^tm1.1Pmc/Pnkp^tm1.1Pmc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnkp^tm1.1Pmc mutation (0 available); any Pnkp mutation (36 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:226703 )

• mice do not survive past 5 days of age

cellular

increased brain apoptosis ( J:226703 )

• mice show abundant cell death from E13 onwards throughout the developing nervous system

• apoptosis is seen in the developing cerebellum

decreased cell proliferation ( J:226703 )

• reduction in proliferation is seen in the developing nervous system

abnormal DNA repair ( J:226703 )

impaired double-strand DNA break repair ( J:226703 )

• primary astrocytes show a defect in the repair of DNA double strand breaks after bleomycin treatment

impaired single-strand DNA break repair ( J:226703 )

• primary cortical non-replicating astrocytes show a deficiency in the repair of DNA damage after treatment with ionizing radiation, hydrogen peroxide, or camptothecin

nervous system

intracranial hemorrhage ( J:226703 )

• hemorrhage in the brain

increased brain apoptosis ( J:226703 )

• mice show abundant cell death from E13 onwards throughout the developing nervous system

• apoptosis is seen in the developing cerebellum

abnormal brain interneuron morphology ( J:226703 )

• reduction in cerebellar interneurons

abnormal cerebellar cortex morphology ( J:226703 )

• smaller cortex

• however, the layering of the cortex still occurs

decreased neuron number ( J:226703 )

• reduction in numbers of neurons in the cortex, particularly in later-born upper cortical layers

cardiovascular system

intracranial hemorrhage ( J:226703 )

• hemorrhage in the brain

homeostasis/metabolism

abnormal DNA repair ( J:226703 )

impaired double-strand DNA break repair ( J:226703 )

• primary astrocytes show a defect in the repair of DNA double strand breaks after bleomycin treatment

impaired single-strand DNA break repair ( J:226703 )

• primary cortical non-replicating astrocytes show a deficiency in the repair of DNA damage after treatment with ionizing radiation, hydrogen peroxide, or camptothecin

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