Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation
(2 available);
any
Emx1 mutation
(34 available)
Pnkptm1.1Pmc mutation
(0 available);
any
Pnkp mutation
(38 available)
|
|
|
cellular
|
|
• loss of all dorsal telencephalic progenitors via apoptosis
|
|
|
• proliferation in the cortex is reduced by E15.5 compared with E13.5
|
growth/size/body
|
|
• body size is reduced at P5
|
nervous system
|
|
• loss of all dorsal telencephalic progenitors via apoptosis
|
|
|
• brain size is reduced at P5
|
|
|
• almost complete absence of the cortex
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation
(5 available);
any
Edil3 mutation
(42 available)
Pnkptm1.1Pmc mutation
(0 available);
any
Pnkp mutation
(38 available)
|
|
|
mortality/aging
|
|
• early lethality, with no embryos recovered after E9
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnkptm1.1Pmc mutation
(0 available);
any
Pnkp mutation
(38 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
|
|
|
cellular
|
|
• mice treated with tamoxifen at P10 (3 doses every 2 days) exhibit apoptosis in the dentate gyrus at P20
|
growth/size/body
|
|
• mice treated with tamoxifen at P7 exhibit a decreased body size at P13
• mice treated with tamoxifen at P10 (3 doses every 2 days) exhibit a modest effect on brain size at P20
|
nervous system
|
|
• mice treated with tamoxifen at P10 (3 doses every 2 days) exhibit apoptosis in the dentate gyrus at P20
|
|
|
• mice treated with tamoxifen at P7 exhibit decreased brain size
• however, mice treated with tamoxifen at P21 (3 doses every 2 days) exhibit little overall effect on brain size or structure
|
|
|
• mice treated with tamoxifen at P7 exhibit a reduction in cortical size
|
|
|
• mice treated with tamoxifen at P21 (3 doses every 2 days) exhibit a decrease in oligodendrocyte numbers in the dentate gyrus but not in the cortex at P33
|
|
|
• mice treated with tamoxifen at P21 show a reduction of mature neurons in the dentate gyrus, the hippocampal CA3 region and the cerebellum
|
|
|
• myelin-producing oligodendrocytes from mice treated with tamoxifen at P21 show a reduction in myelination
• mice treated with tamoxifen at P10 (3 doses every 2 days) exhibit a loss of myelination in the dentate gyrus at P20
• mice treated with tamoxifen at P14 (3 doses every 2 days) exhibit a loss of myelination of oligodendrocytes at P30
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm2Pmc mutation
(0 available);
any
Atm mutation
(169 available)
Pnkptm1.1Pmc mutation
(0 available);
any
Pnkp mutation
(38 available)
Tg(Nes-cre)1Kln mutation
(4 available)
|
|
|
cardiovascular system
|
|
• hemorrhage in the brain
|
cellular
|
|
• apoptosis in the developing cerebellum is similar to single conditional Pnkp mutants
|
nervous system
|
|
• hemorrhage in the brain
|
|
|
• apoptosis in the developing cerebellum is similar to single conditional Pnkp mutants
|
|
|
• reduction in cerebellar interneurons
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnkptm1.1Pmc mutation
(0 available);
any
Pnkp mutation
(38 available)
Tg(Nes-cre)1Kln mutation
(4 available)
|
|
|
mortality/aging
|
|
• mice do not survive past 5 days of age
|
cellular
|
|
• mice show abundant cell death from E13 onwards throughout the developing nervous system
• apoptosis is seen in the developing cerebellum
|
|
|
• reduction in proliferation is seen in the developing nervous system
|
|
|
• primary astrocytes show a defect in the repair of DNA double strand breaks after bleomycin treatment
|
|
|
• primary cortical non-replicating astrocytes show a deficiency in the repair of DNA damage after treatment with ionizing radiation, hydrogen peroxide, or camptothecin
|
nervous system
|
|
• hemorrhage in the brain
|
|
|
• mice show abundant cell death from E13 onwards throughout the developing nervous system
• apoptosis is seen in the developing cerebellum
|
|
|
• reduction in cerebellar interneurons
|
|
|
• smaller cortex
• however, the layering of the cortex still occurs
|
|
|
• reduction in numbers of neurons in the cortex, particularly in later-born upper cortical layers
|
cardiovascular system
|
|
• hemorrhage in the brain
|
homeostasis/metabolism
Analysis Tools