Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm5.1Gfng mutation
(1 available);
any
Shank3 mutation
(77 available)
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behavior/neurological
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• decreased total distance travelled in open field test as compared to controls
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• mice spend less time in open arm during elevated zero maze test as compared to controls
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• impaired motor coordination in rotarod test
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nervous system
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• decreased pop spike amplitude in the dorsal striatum as compared to controls
• presynaptic function, as determined by relationship of stimulation intensity to negative peak amplitude, is similar to control
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm5.1Gfng mutation
(1 available);
any
Shank3 mutation
(77 available)
Tg(CAG-cre/Esr1*)1Lbe mutation
(0 available)
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behavior/neurological
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• prior to tamoxifen administration, mice exhibit decreased total distance travelled in open field test as compared to controls
• following tamoxifen administration, phenotype is unchanged
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• prior to tamoxifen administration, mice spend less time in open arm during elevated zero maze test as compared to controls
• following tamoxifen administration at P20-21, mice exhibit reduced anxiety in the maze test
• tamoxifen administration in adult mice results in an unchanged phenotype
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• prior to tamoxifen administration, mice exhibit repetitive grooming
• following tamoxifen administration, grooming is similar to control
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• prior to tamoxifen administration, mice exhibit decreased latency to fall in rotarod test as compared to controls
• following tamoxifen administration at P20-21, mice perform significantly better on rotarod
• tamoxifen administration in adult mice results in an unchanged phenotype
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• prior to tamoxifen administration, mice exhibit reduced rearing time and frequency as compared to controls
• following tamoxifen administration, phenotype is unchanged
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• prior to tamoxifen administration, mice exhibit no preference for a stranger mouse or novel object in a test of voluntary social interaction
• following tamoxifen administration, mice exhibit a preference for a stranger mouse over a novel object in a test of voluntary social interaction
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growth/size/body
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• as compared to wild-type mice (no tamoxifen administered)
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nervous system
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• prior to tamoxifen administration, mice exhibit a reduction of spine density in medium spiny neurons as compared to controls
• following tamoxifen administration, spine density is increased to a greater density than controls
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• prior to tamoxifen administration, mice exhibit a reduction of spine density in medium spiny neurons
• following tamoxifen administration, spine density is increased to a greater density than controls
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• prior to tamoxifen administration, mice exhibit a reduced field population spikes in the dorsal striatum as compared to controls
• following tamoxifen administration, mice exhibit field responses similar to control
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• prior to tamoxifen administration, mice exhibit a reduced mEPSC frequency as compared to controls
• following tamoxifen administration, mice exhibit mEPSC frequencies similar to control
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Analysis Tools