Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation
(1 available);
any
Mc1r mutation
(43 available)
Tg(Tyr-cre/ERT2)13Bos mutation
(12 available)
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pigmentation
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• following TAM treatment, mice exhibit a yellow coat color at 2nd telogen, similar to mice homozygous for the Mc1re allele
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integument
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• following TAM treatment, mice exhibit a yellow coat color at 2nd telogen, similar to mice homozygous for the Mc1re allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation
(1 available);
any
Mc1r mutation
(43 available)
Tg(CMV-cre)1Cgn mutation
(6 available)
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pigmentation
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• mice exhibit a yellow coat color at 2nd telogen, similar to mice homozygous for the Mc1re allele
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integument
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• mice exhibit a yellow coat color at 2nd telogen, similar to mice homozygous for the Mc1re allele
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pigmentation
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• following wounding, mice show a significant increase of epidermal melanocytes containing dark pigment in the wound site, indicating that Edn1 overexpression in epithelial cells can rescue the defect of epidermal melanocyte regeneration caused by MC1R loss in the melanocyte lineage
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integument
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• following wounding, mice show a significant increase of epidermal melanocytes containing dark pigment in the wound site, indicating that Edn1 overexpression in epithelial cells can rescue the defect of epidermal melanocyte regeneration caused by MC1R loss in the melanocyte lineage
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation
(1 available);
any
Mc1r mutation
(43 available)
Tg(CMV-cre)1Cgn mutation
(6 available)
Tg(Dct-lacZ)#Ove mutation
(0 available)
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pigmentation
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• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice
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integument
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• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation
(1 available);
any
Mc1r mutation
(43 available)
Tg(Dct-lacZ)#Ove mutation
(0 available)
Tg(Tyr-cre/ERT2)13Bos mutation
(12 available)
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pigmentation
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• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice
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integument
|
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• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation
(1 available);
any
Mc1r mutation
(43 available)
Tg(Dct-lacZ)#Ove mutation
(0 available)
Tg(Krt1-15-cre/PGR*)22Cot mutation
(2 available)
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pigmentation
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N |
• following wounding, mice show no differences in the recruitment of epidermal melanocytes to the wound area relative to control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation
(1 available);
any
Mc1r mutation
(43 available)
Tg(Krt1-15-cre/PGR*)22Cot mutation
(2 available)
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pigmentation
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N |
• after RU486 treatment, mice exhibit no defects in coat/hair pigmentation at 2nd telogen relative to control mice
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Analysis Tools