About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ffar3tm2.1Soff
targeted mutation 2.1, Stefan Offermanns
MGI:5770448
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ffar2tm2Soff/Ffar2tm2Soff
Ffar3tm2.1Soff/Ffar3tm2.1Soff
Tg(Vil1-cre)997Gum/0 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL MGI:5770568
cn2
 		Ffar2tm2Soff/Ffar2tm2Soff
Ffar3tm2.1Soff/Ffar3tm2.1Soff
Tg(Ins2-cre)25Mgn/0 		involves: 129S4/SvJae * C57BL/6 * DBA MGI:5770569


Genotype
MGI:5770568
cn1
Allelic
Composition		 Ffar2tm2Soff/Ffar2tm2Soff
Ffar3tm2.1Soff/Ffar3tm2.1Soff
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ffar2tm2Soff mutation (0 available); any Ffar2 mutation (25 available)
Ffar3tm2.1Soff mutation (0 available); any Ffar3 mutation (16 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:227939 )
N
• plasma insulin levels are normal after acetate treatment
• mice fed a high-fat diet and treated with either intraperitoneal injection or oral glucose challenge exhibit normal glucose tolerance, plasma free fatty acid levels and insulin secretion




Genotype
MGI:5770569
cn2
Allelic
Composition		 Ffar2tm2Soff/Ffar2tm2Soff
Ffar3tm2.1Soff/Ffar3tm2.1Soff
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ffar2tm2Soff mutation (0 available); any Ffar2 mutation (25 available)
Ffar3tm2.1Soff mutation (0 available); any Ffar3 mutation (16 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal insulin secretion ( J:227939 )
• loss of acetate-induced PTX-sensitive inhibition of glucose stimulated insulin secretion
increased circulating insulin level ( J:227939 )
• in mice fed a high-fat diet
decreased circulating free fatty acids level ( J:227939 )
• in mice fed a high-fat diet
improved glucose tolerance ( J:227939 )
• in mice fed a high-fat diet

endocrine/exocrine glands
abnormal insulin secretion ( J:227939 )
• loss of acetate-induced PTX-sensitive inhibition of glucose stimulated insulin secretion




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory