Ffar3^tm2.1Soff
Targeted Allele Detail

Summary

• Symbol: Ffar3^tm2.1Soff
• Name: free fatty acid receptor 3; targeted mutation 2.1, Stefan Offermanns
• MGI ID: MGI:5770448
• Gene: Ffar3 Location: Chr7:30553755-30555603 bp, - strand Genetic Position: Chr7, 19.25 cM
• Alliance: Ffar3^tm2.1Soff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227939
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced the coding exon. Cre-mediated recombination removed the selection cassette and left a loxP site. (J:227939)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ffar3 Mutation: 16 strains or lines available

Notes

This allele was generated in ES cells containing Ffar2^tm2Soff.

References

• Original: J:227939 Tang C, et al., Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes. Nat Med. 2015 Feb;21(2):173-7
• All: 1 reference(s)