Phenotypes associated with this allele

• Allele Symbol: Il2ra^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5766766
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il2ra^tm1b(EUCOMM)Wtsi/Il2ra^tm1b(EUCOMM)Wtsi	C57BL/6N-Il2ra^tm1b(EUCOMM)Wtsi/Orl	MGI:6262693

Genotype
MGI:6262693

hm1

• Allelic Composition: Il2ra^{tm1b(EUCOMM)Wtsi}/Il2ra^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Il2ra^{tm1b(EUCOMM)Wtsi}/Orl
• Cell Lines: EPD0822_3_A12

Data Sources

IMPC Data for Il2ra

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:211773 )

♀

IMPC - ICS

decreased exploration in new environment ( J:211773 )

IMPC - ICS

abnormal freezing behavior ( J:211773 )

♀

IMPC - ICS

abnormal locomotor behavior ( J:211773 )

IMPC - ICS

decreased vertical activity ( J:211773 )

♀

IMPC - ICS

decreased locomotor activity ( J:211773 )

IMPC - ICS

cardiovascular system

decreased heart weight ( J:211773 )

♂

IMPC - ICS

prolonged PR interval ( J:211773 )

♂

IMPC - ICS

digestive/alimentary system

abnormal colon morphology ( J:211773 )

♂

IMPC - ICS

abnormal duodenum morphology ( J:211773 )

♂

IMPC - ICS

growth/size/body

decreased body length ( J:211773 )

♂

IMPC - ICS

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

♂

IMPC - ICS

decreased hematocrit ( J:211773 )

♂

IMPC - ICS

decreased hemoglobin content ( J:211773 )

♂

IMPC - ICS

decreased mean corpuscular hemoglobin ( J:211773 )

♂

IMPC - ICS

decreased mean corpuscular hemoglobin concentration ( J:211773 )

♂

IMPC - ICS

decreased mean corpuscular volume ( J:211773 )

♂

IMPC - ICS

increased neutrophil cell number ( J:211773 )

♂

IMPC - ICS

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - ICS

increased large unstained cell number ( J:211773 )

♂

IMPC - ICS

abnormal spleen morphology ( J:211773 )

IMPC - ICS

homeostasis/metabolism

decreased blood urea nitrogen level ( J:211773 )

♀

IMPC - ICS

decreased circulating glucose level ( J:211773 )

♀

IMPC - ICS

decreased circulating calcium level ( J:211773 )

IMPC - ICS

increased circulating phosphate level ( J:211773 )

♂

IMPC - ICS

decreased circulating alkaline phosphatase level ( J:211773 )

IMPC - ICS

increased circulating aspartate transaminase level ( J:211773 )

♀

IMPC - ICS

decreased circulating serum albumin level ( J:211773 )

IMPC - ICS

decreased circulating total protein level ( J:211773 )

IMPC - ICS

improved glucose tolerance ( J:211773 )

♂

IMPC - ICS

abnormal cholesterol homeostasis ( J:211773 )

♀

IMPC - ICS

decreased circulating cholesterol level ( J:211773 )

♀

IMPC - ICS

decreased circulating HDL cholesterol level ( J:211773 )

IMPC - ICS

immune system

increased neutrophil cell number ( J:211773 )

♂

IMPC - ICS

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - ICS

increased large unstained cell number ( J:211773 )

♂

IMPC - ICS

abnormal spleen morphology ( J:211773 )

IMPC - ICS

enlarged lymph nodes ( J:211773 )

IMPC - ICS

skeleton

abnormal vertebrae morphology ( J:211773 )

♀

IMPC - ICS

decreased bone mineral density ( J:211773 )

♂

IMPC - ICS