Phenotypes associated with this allele

• Allele Symbol: kavh
• Allele Name: kidney adysplasia and variable hydronephrosis
• Allele ID: MGI:5763628
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	kavh/kavh	mixed	MGI:5763639
cx2	kavh/kavh^+ Osr1^tm1Jian/Osr1^+	mixed	MGI:5763640

Genotype
MGI:5763639

hm1

• Allelic Composition: kavh/kavh
• Genetic Background: mixed

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

hydronephrosis ( J:226961 )

renal hypoplasia ( J:226961 )

absent kidney ( J:226961 )

• sporadic kidney agenesis

single kidney ( J:226961 )

hearing/vestibular/ear

abnormal ear morphology ( J:226961 )

• possible auditory defects

increased or absent threshold for auditory brainstem response ( J:226961 )

impaired hearing ( J:226961 )

• as early as 3 weeks of age

homeostasis/metabolism

increased blood urea nitrogen level ( J:226961 )

• in mice with hydronephosis

nervous system

hydrocephaly ( J:226961 )

• low-penetrance

cardiovascular system

cardiovascular system phenotype ( J:226961 )

N • mice do not exhibit cardiac abnormalities as in mice with mutations in Osr1

Genotype
MGI:5763640

cx2

• Allelic Composition: kavh/kavh⁺; Osr1^tm1Jian/Osr1⁺
• Genetic Background: mixed

mortality/aging

neonatal lethality, complete penetrance ( J:226961 )

• mice die prenatally or within 24 hours of birth

prenatal lethality, incomplete penetrance ( J:226961 )

• mice die prenatally or within 24 hours of birth

renal/urinary system

absent kidney ( J:226961 )

• at P0 in all mice