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Osr1 Gene Detail
Summary
  • Symbol
    Osr1
  • Name
    odd-skipped related transcription factor 1
  • Synonyms
    Odd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344424
    NCBI Gene: 23967
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:9624442-9631500 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 4.05 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344424
 protein coding gene Chr12:9620116-9631500 (+)
129S1/SvImJ ENSMUSG00200023058
 protein coding gene Chr12:6592700-6604074 (+)
A/J ENSMUSG00195015686
 protein coding gene Chr12:6633909-6645273 (+)
AKR/J ENSMUSG00220028710
 protein coding gene Chr12:6670160-6681538 (+)
BALB/cJ ENSMUSG00180014860
 protein coding gene Chr12:6626421-6637791 (+)
C3H/HeJ ENSMUSG00175008903
 protein coding gene Chr12:6622957-6634333 (+)
C57BL/6NJ ENSMUSG00215008582
 protein coding gene Chr12:6457308-6468694 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017609
 protein coding gene Chr12:6284141-6291146 (+)
CAST/EiJ ENSTCUG00005021507
 protein coding gene Chr12:6304832-6316328 (+)
CBA/J ENSMUSG00210013076
 protein coding gene Chr12:6653590-6664966 (+)
DBA/2J ENSMUSG00185019737
 protein coding gene Chr12:6596309-6607698 (+)
FVB/NJ ENSMUSG00205002683
 protein coding gene Chr12:6353074-6364451 (+)
JF1/MsJ ENSUMUG00000018244
 protein coding gene Chr12:6549751-6561152 (+)
LP/J ENSMUSG00230011413
 protein coding gene Chr12:8426292-8437687 (+)
NOD/ShiLtJ ENSMUSG00190007731
 protein coding gene Chr12:7840592-7851960 (+)
NZO/HlLtJ ENSMUSG00225029897
 protein coding gene Chr12:10505456-10516844 (+)
PWK/PhJ ENSLUMG00010016236
 protein coding gene Chr12:6286825-6298287 (+)
SPRET/EiJ ENSMSPG00010004729
 protein coding gene Chr12:6967175-6978604 (+)
WSB/EiJ ENSIUOG00005002037
 protein coding gene Chr12:6622507-6633893 (+)



Homology
more
  • Human Ortholog
    OSR1, odd-skipped related transcription factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OSR1, odd-skipped related transcription factor 1
  • Synonyms
    ODD
  • Links
    NCBI Gene ID: 130497
    UniProt: Q8TAX0

  • Chr Location
    2p24.1; chr2:19344874-19359486 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 6 alleles in 7 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation fail to form atrial septum and exhibit dilated atria with hypoplastic venous valves and blood backflow from the heart into systemic veins. Complete agenesis of adrenal glands, metanephric kidneys, gonads, and defects in pericardium formation are also observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1211
  • Tissues
    241
  • cDNA Data
    28
  • Literature Summary
    92
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23967 NCBI Gene Model | MGI Sequence Detail 7059 C57BL/6J ±  kb
    transcript NM_011859 RefSeq | MGI Sequence Detail 2027 ZRU/MplStud  
    polypeptide Q9WVG7 UniProt | EBI | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 1
      cDNA 30
      Primer pair 11
      Other 9

      Microarray probesets 3
    References
    more
    • Summaries
      All 147
      Developmental Gene Expression 92
      Gene Ontology 16
      Phenotypes 39
    • Earliest
      J:56366 So PL, et al., Cloning and expression analysis of a mouse gene related to Drosophila odd-skipped. Mech Dev. 1999 Jun;84(1-2):157-60
    • Latest
      J:387872 Jafree DJ, et al., Osr1-expressing mesoderm contributes to lymphatic vessel assembly and complexity in the mammalian kidney. Cell Rep. 2026 Jun 19;:117560
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory