Phenotypes associated with this allele

• Allele Symbol: Epyc^tm1Mhok
• Allele Name: targeted mutation 1, Magnus Hook
• Allele ID: MGI:5762921
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epyc^tm1Mhok/Epyc^tm1Mhok	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5762922
cx2	Bgn^tm1Mfy/Bgn^tm1Mfy Epyc^tm1Mhok/Epyc^tm1Mhok	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	MGI:5762923

Genotype
MGI:5762922

hm1

• Allelic Composition: Epyc^tm1Mhok/Epyc^tm1Mhok
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

osteoarthritis ( J:222369 )

• borderline in 2 of 4 mice at 9 months

short femur ( J:222369 )

♂ • in male mice at 9 months

immune system

osteoarthritis ( J:222369 )

• borderline in 2 of 4 mice at 9 months

limbs/digits/tail

short femur ( J:222369 )

♂ • in male mice at 9 months

Genotype
MGI:5762923

cx2

• Allelic Composition: Bgn^tm1Mfy/Bgn^tm1Mfy; Epyc^tm1Mhok/Epyc^tm1Mhok
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

skeleton

osteoarthritis ( J:222369 )

• severe in all mice with ligament and tendon ossification as early as 3 months of age

short femur ( J:222369 )

• in female and male mice at 9 months

osteophytes ( J:222369 )

growth/size/body

decreased body weight ( J:222369 )

• at 9 months

homeostasis/metabolism

decreased collagen level ( J:222369 )

immune system

osteoarthritis ( J:222369 )

• severe in all mice with ligament and tendon ossification as early as 3 months of age

limbs/digits/tail

short femur ( J:222369 )

• in female and male mice at 9 months