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Targeted Allele Detail
Symbol: Epyctm1Mhok
Name: epiphycan; targeted mutation 1, Magnus Hook
MGI ID: MGI:5762921
Gene: Epyc  Location: Chr10:97479930-97517770 bp, + strand  Genetic Position: Chr10, 50.35 cM, cytoband C2-C3
Alliance: Epyctm1Mhok page
Germline Transmission:  Earliest citation of germline transmission: J:222369
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsThe targeting constructs introduced into exon 3 6 bp downstream of the translation initiation sequence a lacZ reporter gene and a floxed neomycin resistance cassette. Immunohistochemistry confirmed the absence of protein expression in the knee joint. (J:222369)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epyc Mutation:  21 strains or lines available
Original:  J:222369 Nuka S, et al., Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice. Osteoarthritis Cartilage. 2010 Jan;18(1):88-96
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.24
The Jackson Laboratory