All Phenotypes Lmna<tm4Stw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lmna^tm4Stw
targeted mutation 4, Colin L Stewart
MGI:5750954

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lmna^tm4Stw/Lmna^tm4Stw Tg(Vil1-cre)997Gum/0	involves: C57BL/6 * C57BL/6J	MGI:5774438
cn2	Apc^Min/Apc⁺ Lmna^tm4Stw/Lmna^tm4Stw Tg(Vil1-cre)997Gum/0	involves: C57BL/6 * C57BL/6J	MGI:5774439
cn3	Lmna^tm4Stw/Lmna^tm4Stw Tg(Zp3-cre)93Knw/0	involves: C57BL/6J	MGI:5774437

Allelic Composition	Lmna^tm4Stw/Lmna^tm4Stw Tg(Vil1-cre)997Gum/0
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm4Stw mutation (0 available); any Lmna mutation (82 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:220874 )

• mice are born at normal Mendelian ratios and survive for >1 year with no gross defects, such as shortened lifespan or reduced weight

• H&E staining showed normal gastrointestinal (GI) tract histology (duodenum, jejunum, ileum and colon) at 10 weeks of age

• Ki67 staining revealed normal GI epithelial proliferation at 1 year of age

Allelic Composition	Apc^Min/Apc⁺ Lmna^tm4Stw/Lmna^tm4Stw Tg(Vil1-cre)997Gum/0
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Lmna^tm4Stw mutation (0 available); any Lmna mutation (82 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

duodenum polyps ( J:220874 )

• at 16-32 weeks of age, mice show a 1.5-fold increase in the frequency of larger polyps (2-5 mm) in the duodenum relative to Apc^Min heterozygous controls

jejunum polyps ( J:220874 )

• mice show a 3-fold increase in the frequency of larger polyps (2-5 mm) in the proximal jejunum relative to Apc^Min heterozygous controls

• however, the total number of polyps found in the gastrointestinal tract (duodenum, proximal and distal jejunum, ileum and colon) is not significantly altered relative to ApcMin heterozygous controls

Allelic Composition	Lmna^tm4Stw/Lmna^tm4Stw Tg(Zp3-cre)93Knw/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm4Stw mutation (0 available); any Lmna mutation (82 available)
Tg(Zp3-cre)93Knw mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:220874 )

• mice are born at normal Mendelian ratios but survive only to P12-P18

growth/size/body

decreased body size ( J:220874 )

• by P14, mice of both sexes are significantly smaller than wild-type or heterozygous controls

decreased body weight ( J:220874 )

• by P12-P14, body weight is ~50% that of wild-type or heterozygous controls

postnatal growth retardation ( J:220874 )

• mice exhibit retarded growth from P10 onwards

behavior/neurological

abnormal gait ( J:220874 )

• mice display a stiff walking posture

muscle

decreased skeletal muscle fiber diameter ( J:220874 )

• significantly smaller diameter myofibrils in quadriceps muscles

centrally nucleated skeletal muscle fibers ( J:220874 )

• increased incidence of centrally located nuclei in quadriceps muscles

dystrophic muscle ( J:220874 )

limbs/digits/tail

kinked tail ( J:220874 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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