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Allele Symbol Allele Name Allele ID |
Glultm1.1Geno targeted mutation 1.1, Genoway MGI:5750936 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable and fertile and exhibit intact liver architecture and zonation, absence of liver damage, a functional urea cycle, normal ammonia homeostasis, and no behavioral or motor deficits, similar to wild-type controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
RNA oxidation in Glultm1.1Geno/Glultm1.1Geno Speer6-ps1Tg(Alb-cre)21Mgn/0 mouse brain
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• mice exhibit a slightly reduced life span relative to controls
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| N |
• mice exhibit normal serum activities of aspartate and alanine aminotransferases indicating absence of liver damage
• no differences in serum and urine urea nitrogen or serum glutamine, glutamate or alanine concentrations are observed indicating a functional urea cycle
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• significantly elevated plasma ammonia levels at 8-9 weeks and 12-14 months of age
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• induction of oxidative stress in specific brain regions, as shown by increased protein Tyr nitration and RNA oxidation in the cerebellum, hippocampus, and somatosensory cortex, but not in the piriform cortex, relative to controls
• unusually high levels of oxidized RNA in cerebellar Purkinje cells
• however, no evidence of microglia activation or increased synthesis of proinflammatory cytokines in the cerebral cortex
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• impaired fear memory in the O-Maze test, as shown by increased time spent in the open arms and decreased time spent in the protected (closed) arms relative to controls
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• increased total activity time, activity counts, and distance traveled at 24 hrs after transfer into a light barrier-equipped cage relative to controls
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| N |
• mice exhibit intact liver architecture and zonation relative to controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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