All Phenotypes Tlr5<tm1.1Gewr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Il10^tm1Cgn/Il10^tm1Cgn Tg(Vil1-cre)997Gum/? Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL	MGI:5751560
cn2	Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Tg(Itgax-cre,-EGFP)4097Ach/?	involves: C57BL/6J * C57BL/6NTac	MGI:5751549
cn3	Tg(Vil1-cre)997Gum/? Tlr4^lps-del/Tlr4^lps-del Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr	involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL	MGI:5751557
cn4	Tg(Vil1-cre)997Gum/? Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr	involves: C57BL/6J * C57BL/6NTac * SJL/J	MGI:5751550
cx5	Il10^tm1Cgn/Il10^tm1Cgn Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac	MGI:5751562

Allelic Composition	Il10^tm1Cgn/Il10^tm1Cgn Tg(Vil1-cre)997Gum/? Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10^tm1Cgn mutation (15 available); any Il10 mutation (44 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Tlr5^tm1.1Gewr mutation (1 available); any Tlr5 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

rectal prolapse ( J:229155 )

• 100% of mice develop rectal prolapse by approximately 75 days

abnormal gut flora balance ( J:229155 )

• increase in levels of fecal bacteria as compared to Il10 mutation alone

colitis ( J:229155 )

• severe uniform colitis in 100% of mice; presence of intestinal endothelial cell (IEC)-specific Tlr5 null mutation exacerbates phenotype

• increased incidence of rectal prolapse; presence of IEC-specific Tlr5 null mutation exacerbates phenotype

immune system

colitis ( J:229155 )

• severe uniform colitis in 100% of mice; presence of intestinal endothelial cell (IEC)-specific Tlr5 null mutation exacerbates phenotype

• increased incidence of rectal prolapse; presence of IEC-specific Tlr5 null mutation exacerbates phenotype

mortality/aging

premature death ( J:229155 )

• mice are euthanized due to rectal prolapse

Allelic Composition	Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic Background	involves: C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)
Tlr5^tm1.1Gewr mutation (1 available); any Tlr5 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total fat pad weight ( J:229155 )

digestive/alimentary system

abnormal gut flora balance ( J:229155 )

• delayed clearance of pathobiont bacteria

• decreased distance of fecal bacteria from intestinal epithelial cells

immune system

immune system phenotype ( J:229155 )

N	• mice do not exhibit spontaneous colitis, low grade inflammation or metabolic syndrome

Allelic Composition	Tg(Vil1-cre)997Gum/? Tlr4^lps-del/Tlr4^lps-del Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr
Genetic Background	involves: C57BL/6J * C57BL/6NTac * C57BL/10ScN * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tlr4^lps-del mutation (6 available); any Tlr4 mutation (90 available)
Tlr5^tm1.1Gewr mutation (1 available); any Tlr5 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:229155 )

N	• mice do not exhibit symptoms of metabolic syndrome • fat pad weight, body weight, spleen weight, colon weight, and fasting glucose levels are similar to wild-type

behavior/neurological

polyphagia ( J:229155 )

digestive/alimentary system

abnormal colon morphology ( J:229155 )

• increased colon weight

decreased colon length ( J:229155 )

large intestinal inflammation ( J:229155 )

• low grade inflammation, however, phenotype is less severe than in mice with wild-type Tlr4

immune system

large intestinal inflammation ( J:229155 )

• low grade inflammation, however, phenotype is less severe than in mice with wild-type Tlr4

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total fat pad weight ( J:229155 )

• increased adiposity on chow and high fat diet

behavior/neurological

polyphagia ( J:229155 )

digestive/alimentary system

abnormal colon morphology ( J:229155 )

• shorter and heavier colons on chow diet

• increased colon weight on high fat diet, length is similar to wild-type

decreased colon length ( J:229155 )

abnormal gut flora balance ( J:229155 )

• increase in levels of fecal bacteria

• increase in levels of bacteria adherent to the colonic mucosa

• decreased distance of bacteria from intestinal epithelial cells

• delayed clearance of pathobiont bacteria

• alteration in microbiota composition as compared to controls

large intestinal inflammation ( J:229155 )

• low grade inflammation, however mice do not develop spontaneous colitis

increased susceptibility to colitis induced morbidity/mortality ( J:229155 )

• increased mortality observed in mice on low dose DSS

growth/size/body

increased body weight ( J:229155 )

• on chow and high fat diet

enlarged spleen ( J:229155 )

• mild splenomegaly on chow and high fat diet

hematopoietic system

enlarged spleen ( J:229155 )

• mild splenomegaly on chow and high fat diet

homeostasis/metabolism

increased fasting circulating glucose level ( J:229155 )

• increased levels of blood glucose in males following 15 hr fast

• high fat diet compounds hyperglycemia especially in female mice

increased circulating cholesterol level ( J:229155 )

• in males

increased circulating triglyceride level ( J:229155 )

• in males

immune system

large intestinal inflammation ( J:229155 )

• low grade inflammation, however mice do not develop spontaneous colitis

increased susceptibility to colitis induced morbidity/mortality ( J:229155 )

• increased mortality observed in mice on low dose DSS

enlarged spleen ( J:229155 )

• mild splenomegaly on chow and high fat diet

increased interleukin-1 beta secretion ( J:229155 )

• increased levels of colonic IL1B secretion in males treated with DSS

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:229155 )

• increased mortality observed in mice on low dose DSS

Allelic Composition	Il10^tm1Cgn/Il10^tm1Cgn Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10^tm1Cgn mutation (15 available); any Il10 mutation (44 available)
Tlr5^tm1.1Gewr mutation (1 available); any Tlr5 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

rectal prolapse ( J:229155 )

• most mice develop rectal prolapse by 150 days

colitis ( J:229155 )

• severe colitis in 100% of mice; phenotype is less severe than in the presence of the intestinal endothelial cell (IEC)-specific Tlr5 null mutation

immune system

colitis ( J:229155 )

• severe colitis in 100% of mice; phenotype is less severe than in the presence of the intestinal endothelial cell (IEC)-specific Tlr5 null mutation

mortality/aging

premature death ( J:229155 )

• mice are euthanized by 5 months due to rectal prolapse

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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