Phenotypes associated with this allele

• Allele Symbol: Trp53^tm2.1Umol
• Allele Name: targeted mutation 2.1, Ute Moll
• Allele ID: MGI:5708410
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm2.1Umol/Trp53^tm2.1Umol	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5790360
ht2	Trp53^tm1Tyj/Trp53^tm2.1Umol	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5790358

Genotype
MGI:5790360

hm1

• Allelic Composition: Trp53^tm2.1Umol/Trp53^tm2.1Umol
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:228632 )

• mice show similar survival to single Trp53^tm1Tyj homozygotes

• however, beyond 230 days, mice show a trend toward survival extension compared to single Trp53^tm1Tyj homozygotes, most likely due to a reduction in very late appearing B lymphomas

neoplasm

increased T cell derived lymphoma incidence ( J:228632 )

• mice show similar tumor latency as single Trp53^tm1Tyj homozygotes

increased B cell derived lymphoma incidence ( J:228632 )

• mice show similar tumor latency as single Trp53^tm1Tyj homozygotes

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:228632 )

• mice show similar tumor latency as single Trp53^tm1Tyj homozygotes

immune system

increased T cell derived lymphoma incidence ( J:228632 )

• mice show similar tumor latency as single Trp53^tm1Tyj homozygotes

hematopoietic system

increased T cell derived lymphoma incidence ( J:228632 )

• mice show similar tumor latency as single Trp53^tm1Tyj homozygotes

Genotype
MGI:5790358

ht2

• Allelic Composition: Trp53^tm1Tyj/Trp53^tm2.1Umol
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

mortality/aging

premature death ( J:228632 )

• mice show similar survival to single Trp53^tm1Tyj homozygotes

• however, beyond 230 days, mice show a trend toward survival extension compared to single Trp53^tm1Tyj homozygotes, most likely due to a reduction in very late appearing B lymphomas

neoplasm

increased lymphoma incidence ( J:228632 )

• lymphomas show a decrease in cell proliferation compared to lymphomas from compound heterozygous Trp53^tm1.1Umol/Trp53^tm1Tyj mice

increased T cell derived lymphoma incidence ( J:228632 )

• mice show similar tumor latency as single Trp53^tm1Tyj homozygotes

increased B cell derived lymphoma incidence ( J:228632 )

• mice show similar tumor latency as single Trp53^tm1Tyj homozygotes

increased carcinoma incidence ( J:228632 )

• mice show broadening of the tumor spectrum, showing more carcinomas compared with single Trp53^tm1Tyj homozygotes

increased sarcoma incidence ( J:228632 )

• mice show broadening of the tumor spectrum, showing a higher diversity of sarcoma subtypes compared with single Trp53^tm1Tyj homozygotes

increased reproductive system tumor incidence ( J:228632 )

• mice show broadening of the tumor spectrum, showing more germ cell tumors compared with single Trp53^tm1Tyj homozygotes

reproductive system

increased reproductive system tumor incidence ( J:228632 )

• mice show broadening of the tumor spectrum, showing more germ cell tumors compared with single Trp53^tm1Tyj homozygotes

cellular

decreased cellular sensitivity to gamma-irradiation ( J:228632 )

• thymocytes are resistant to apoptosis after gamma-irradiation

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:228632 )

• mice show similar tumor latency as single Trp53^tm1Tyj homozygotes

hematopoietic system

increased T cell derived lymphoma incidence ( J:228632 )

• mice show similar tumor latency as single Trp53^tm1Tyj homozygotes

increased hematopoietic stem cell number ( J:228632 )

• mice show a similar increase in the number of hematopoietic Lin-Sca1+c-Kit+ (LSK) progenitor cells as single Trp53^tm1Tyj homozygotes

immune system

increased T cell derived lymphoma incidence ( J:228632 )

• mice show similar tumor latency as single Trp53^tm1Tyj homozygotes