Phenotypes associated with this allele

• Allele Symbol: Trp53^tm1.1Umol
• Allele Name: targeted mutation 1.1, Ute Moll
• Allele ID: MGI:5708402
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1.1Umol/Trp53^tm1.1Umol	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5790355
ht2	Trp53^tm1Tyj/Trp53^tm1.1Umol	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5790354

Genotype
MGI:5790355

hm1

• Allelic Composition: Trp53^tm1.1Umol/Trp53^tm1.1Umol
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:228632 )

• shortened survival compared to single Trp53^tm1Tyj homozygotes

neoplasm

increased T cell derived lymphoma incidence ( J:228632 )

• accelerated tumor onset of T lymphomas compared to single Trp53^tm1Tyj homozygotes

increased B cell derived lymphoma incidence ( J:228632 )

• accelerated tumor onset of B lymphomas compared to single Trp53^tm1Tyj homozygotes

decreased tumor latency ( J:228632 )

• accelerated tumor onset of T lymphomas, B lymphomas, and solid tumors compared to single Trp53^tm1Tyj homozygotes

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:228632 )

• accelerated tumor onset of T lymphomas compared to single Trp53^tm1Tyj homozygotes

Genotype
MGI:5790354

ht2

• Allelic Composition: Trp53^tm1Tyj/Trp53^tm1.1Umol
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

mortality/aging

premature death ( J:228632 )

• shortened survival compared to single Trp53^tm1Tyj homozygotes

neoplasm

increased leukemia incidence ( J:228632 )

• T-lymphoma cell lines established from mutant mice develop into highly aggressive leukemias when tail vein injected into the circulation of nude mice

increased lymphoma incidence ( J:228632 )

• lymphomas show a 2-fold increase in cell proliferation compared to lymphomas from Trp53^tm1Tyj homozygotes and compound heterozygous Trp53^tm2.1Umol/Trp53^tm1Tyj mice

increased T cell derived lymphoma incidence ( J:228632 )

• accelerated tumor onset of T lymphomas compared to single Trp53^tm1Tyj homozygotes

increased B cell derived lymphoma incidence ( J:228632 )

• accelerated tumor onset of B lymphomas compared to single Trp53^tm1Tyj homozygotes

increased carcinoma incidence ( J:228632 )

• mice show broadening of the tumor spectrum, showing more carcinomas compared with single Trp53^tm1Tyj homozygotes

increased sarcoma incidence ( J:228632 )

• mice show broadening of the tumor spectrum, showing a higher diversity of sarcoma subtypes compared with single Trp53^tm1Tyj homozygotes

increased reproductive system tumor incidence ( J:228632 )

• mice show broadening of the tumor spectrum, showing more germ cell tumors compared with single Trp53^tm1Tyj homozygotes

decreased tumor latency ( J:228632 )

• accelerated tumor onset of T lymphomas, B lymphomas, and solid tumors compared to single Trp53^tm1Tyj homozygotes

cellular

decreased cellular sensitivity to gamma-irradiation ( J:228632 )

• thymocytes are resistant to apoptosis after gamma-irradiation

embryo

abnormal mesenchyme morphology ( J:228632 )

• mice show a similar expansion of mesenchymal stem cells as single Trp53^tm1Tyj homozygotes

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:228632 )

• accelerated tumor onset of T lymphomas compared to single Trp53^tm1Tyj homozygotes

hematopoietic system

increased hematopoietic stem cell number ( J:228632 )

• mice show a greater increase in the number of hematopoietic Lin-Sca1+c-Kit+ (LSK) progenitor cells than single Trp53^tm1Tyj homozygotes

reproductive system

increased reproductive system tumor incidence ( J:228632 )

• mice show broadening of the tumor spectrum, showing more germ cell tumors compared with single Trp53^tm1Tyj homozygotes