Analysis Tools
growth/size/body
 N |
• at 8-10 weeks of age, mice exhibit normal body weight relative to control mice
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homeostasis/metabolism
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N |
• at 8-10 weeks of age, baseline serum thyroxine and triiodothyronine concentrations are normal and serum TSH is not suppressed relative to control mice, indicating normal thyroid status in the well state
• serum total protein concentrations are also normal
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• mice exhibit an 81% increase in serum T4 levels between 24 and 48 hrs post CCl4 injection, unlike control mice where serum T4 levels remain suppressed
• comparisons between 0 and 48 hrs post CCl4 injection confirm that serum T4 levels return to near pre-injury levels, unlike in control mice
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• mice exhibit a 76% increase in serum T3 levels between 24 and 48 hrs post CCl4 injection, unlike control mice where serum T3 levels remain suppressed
• comparisons between 0 and 48 hrs post CCl4 injection confirm that serum T4 levels return to near pre-injury levels, unlike in control mice
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• mice display accelerated recovery from CCl4-induced hypothyroxinemia and hypotriiodothyronemia
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liver/biliary system
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N |
• at 8-10 weeks of age, mice exhibit normal liver weight and histology relative to control mice
• following CCl4-induced hepatonecrosis, mice exhibit normal injury tolerance and intact liver regeneration with complete normalization of liver histology at 120 hrs post CCl4 injection, indicating normal local responses to liver injury
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• following CCl4-induced hepatonecrosis, mice exhibit higher expression of proliferating cell markers (PCNA, cyclins A2 and E1) at 48 hrs post CCl4 injection relative to control mice
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cellular
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• following CCl4-induced hepatonecrosis, mice exhibit higher expression of proliferating cell markers (PCNA, cyclins A2 and E1) at 48 hrs post CCl4 injection relative to control mice
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