Dio3^tm1Dmst
Targeted Allele Detail

Summary

• Symbol: Dio3^tm1Dmst
• Name: deiodinase, iodothyronine type III; targeted mutation 1, Domenico Salvatore
• MGI ID: MGI:5707059
• Synonyms: Dio3^flox
• Gene: Dio3 Location: Chr12:110245664-110247531 bp, + strand Genetic Position: Chr12, 60.56 cM, cytoband F1
• Alliance: Dio3^tm1Dmst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218350
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• A floxed allele was generated. (J:218350)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dio3 Mutation: 7 strains or lines available

References

• Original: J:218350 Castroneves LA, et al., Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis. Endocrinology. 2014 Oct;155(10):4061-8
• All: 4 reference(s)