Phenotypes associated with this allele

• Allele Symbol: Tg(RasE)290Biat
• Allele Name: transgene insertion 290, Biomodels Austria
• Allele ID: MGI:5702681
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(RasE)290Biat/0	involves: C57BL/6 * DBA/2	MGI:5770441
cn2	Gt(ROSA)26Sor^tm2(cre/ERT2)Brn/Gt(ROSA)26Sor^+ Tg(RasE)290Biat/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5770438
cn3	Gt(ROSA)26Sor^tm2(cre/ERT2)Brn/Gt(ROSA)26Sor^+ Pten^tm2Mak/Pten^tm2Mak Tg(RasE)290Biat/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5770439
tg4	Tg(RasE)290Biat/0	involves: C57BL/6 * DBA/2	MGI:5770437

Genotype
MGI:5770441

cn1

• Allelic Composition: Tg(RasE)290Biat/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung adenocarcinoma incidence ( J:226601 )

• mice inhaling adenoviral particles expressing cre recombinase (AdCre) develop pan-cytokeratin-positive lung adenocarcinomas; about 85% of tumors show simultaneous activation of the three alleles

• lung tumors expressing all three alleles are slightly bigger than tumors not expressing all three alleles

• substantial percentage of triple allele activated tumors are invasive while non-triple allele activated tumors are noninvasive

• mice inhaling AdCre particles do not develop pancreatic or skin-appendage tumors

respiratory system

increased lung adenocarcinoma incidence ( J:226601 )

• mice inhaling adenoviral particles expressing cre recombinase (AdCre) develop pan-cytokeratin-positive lung adenocarcinomas; about 85% of tumors show simultaneous activation of the three alleles

• lung tumors expressing all three alleles are slightly bigger than tumors not expressing all three alleles

• substantial percentage of triple allele activated tumors are invasive while non-triple allele activated tumors are noninvasive

• mice inhaling AdCre particles do not develop pancreatic or skin-appendage tumors

Genotype
MGI:5770438

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺; Tg(RasE)290Biat/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

neoplasm

increased pancreas tumor incidence ( J:226601 )

• 100% of mice develop lung and pancreatic cancers at between 8 and 12 weeks after tamoxifen injection

increased pancreatic ductal adenocarcinoma incidence ( J:226601 )

• pancreatic tumors of tamoxifen treated mice are intraepithelial neoplasias or pancreatic ductal adenocarcinomas

increased pancreatic intraepithelial neoplasia incidence ( J:226601 )

• pancreatic tumors of tamoxifen treated mice are intraepithelial neoplasias or pancreatic ductal adenocarcinomas

increased sebaceous gland tumor incidence ( J:226601 )

• about 80% of tamoxifen-injected mice develop tumors in the skin which immunohistochemistry suggests are skin-appendage tumors derived from sebaceous glands

• skin-appendage tumors develop when 4-OH tamoxifen is applied atopically onto the back of the skin; 98.3% of tumors show simultaneous activation of the three alleles

increased lung tumor incidence ( J:226601 )

• 100% of mice develop lung and pancreatic cancers at between 8 and 12 weeks after tamoxifen injection

increased lung adenocarcinoma incidence ( J:226601 )

• lung tumors of tamoxifen treated mice are adenocarcinomas

endocrine/exocrine glands

increased pancreas tumor incidence ( J:226601 )

• 100% of mice develop lung and pancreatic cancers at between 8 and 12 weeks after tamoxifen injection

increased pancreatic ductal adenocarcinoma incidence ( J:226601 )

• pancreatic tumors of tamoxifen treated mice are intraepithelial neoplasias or pancreatic ductal adenocarcinomas

increased pancreatic intraepithelial neoplasia incidence ( J:226601 )

• pancreatic tumors of tamoxifen treated mice are intraepithelial neoplasias or pancreatic ductal adenocarcinomas

increased sebaceous gland tumor incidence ( J:226601 )

• about 80% of tamoxifen-injected mice develop tumors in the skin which immunohistochemistry suggests are skin-appendage tumors derived from sebaceous glands

• skin-appendage tumors develop when 4-OH tamoxifen is applied atopically onto the back of the skin; 98.3% of tumors show simultaneous activation of the three alleles

respiratory system

increased lung tumor incidence ( J:226601 )

• 100% of mice develop lung and pancreatic cancers at between 8 and 12 weeks after tamoxifen injection

increased lung adenocarcinoma incidence ( J:226601 )

• lung tumors of tamoxifen treated mice are adenocarcinomas

Genotype
MGI:5770439

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺; Pten^tm2Mak/Pten^tm2Mak; Tg(RasE)290Biat/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

mortality/aging

premature death ( J:226601 )

• tamoxifen treated mice exhibit shortened lifespan

neoplasm

increased pancreas tumor incidence ( J:226601 )

• tamoxifen treated mice exhibit accelerated formation of lung and pancreatic tumors compared to single Tg(RasE)290Biat transgenics

increased lung tumor incidence ( J:226601 )

• tamoxifen treated mice exhibit accelerated formation of lung and pancreatic tumors compared to single Tg(RasE)290Biat transgenics

endocrine/exocrine glands

increased pancreas tumor incidence ( J:226601 )

• tamoxifen treated mice exhibit accelerated formation of lung and pancreatic tumors compared to single Tg(RasE)290Biat transgenics

respiratory system

increased lung tumor incidence ( J:226601 )

• tamoxifen treated mice exhibit accelerated formation of lung and pancreatic tumors compared to single Tg(RasE)290Biat transgenics

Genotype
MGI:5770437

tg4

• Allelic Composition: Tg(RasE)290Biat/0
• Genetic Background: involves: C57BL/6 * DBA/2

neoplasm

neoplasm ( J:226601 )

N • mice do not develop tumors up to 2 years of age