Phenotypes associated with this allele

• Allele Symbol: Lrrk1^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5692778
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrk1^tm1b(KOMP)Wtsi/Lrrk1^tm1b(KOMP)Wtsi	C57BL/6N-Lrrk1^tm1b(KOMP)Wtsi/H	MGI:5757319

Genotype
MGI:5757319

hm1

• Allelic Composition: Lrrk1^{tm1b(KOMP)Wtsi}/Lrrk1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Lrrk1^{tm1b(KOMP)Wtsi}/H
• Cell Lines: EPD0073_6_C01

Data Sources

IMPC Data for Lrrk1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - HAR

behavior/neurological

abnormal locomotor behavior ( J:211773 )

♂

IMPC - HAR

abnormal gait ( J:211773 )

IMPC - HAR

craniofacial

abnormal tooth morphology ( J:211773 )

IMPC - HAR

absent teeth ( J:211773 )

IMPC - HAR

abnormal mandible morphology ( J:211773 )

♂

IMPC - HAR

abnormal maxilla morphology ( J:211773 )

IMPC - HAR

abnormal zygomatic bone morphology ( J:211773 )

IMPC - HAR

abnormal snout morphology ( J:211773 )

♂

IMPC - HAR

endocrine/exocrine glands

small thymus ( J:211773 )

♀

IMPC - HAR

growth/size/body

abnormal tooth morphology ( J:211773 )

IMPC - HAR

absent teeth ( J:211773 )

IMPC - HAR

abnormal snout morphology ( J:211773 )

♂

IMPC - HAR

decreased lean body mass ( J:211773 )

♀

IMPC - HAR

hematopoietic system

small thymus ( J:211773 )

♀

IMPC - HAR

increased red blood cell distribution width ( J:211773 )

IMPC - HAR

increased neutrophil cell number ( J:211773 )

IMPC - HAR

thrombocytopenia ( J:211773 )

IMPC - HAR

decreased leukocyte cell number ( J:211773 )

♂

IMPC - HAR

decreased eosinophil cell number ( J:211773 )

♂

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - HAR

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

♂

IMPC - HAR

increased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - HAR

increased circulating iron level ( J:211773 )

♂

IMPC - HAR

increased circulating phosphate level ( J:211773 )

♂

IMPC - HAR

decreased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - HAR

increased circulating aspartate transaminase level ( J:211773 )

IMPC - HAR

increased circulating creatine kinase level ( J:211773 )

IMPC - HAR

immune system

small thymus ( J:211773 )

♀

IMPC - HAR

increased neutrophil cell number ( J:211773 )

IMPC - HAR

decreased leukocyte cell number ( J:211773 )

♂

IMPC - HAR

decreased eosinophil cell number ( J:211773 )

♂

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - HAR

limbs/digits/tail

abnormal humerus morphology ( J:211773 )

IMPC - HAR

abnormal radius morphology ( J:211773 )

♂

IMPC - HAR

abnormal ulna morphology ( J:211773 )

♂

IMPC - HAR

abnormal femur morphology ( J:211773 )

IMPC - HAR

abnormal fibula morphology ( J:211773 )

IMPC - HAR

abnormal tibia morphology ( J:211773 )

IMPC - HAR

short tibia ( J:211773 )

IMPC - HAR

skeleton

abnormal tooth morphology ( J:211773 )

IMPC - HAR

absent teeth ( J:211773 )

IMPC - HAR

abnormal mandible morphology ( J:211773 )

♂

IMPC - HAR

abnormal maxilla morphology ( J:211773 )

IMPC - HAR

abnormal zygomatic bone morphology ( J:211773 )

IMPC - HAR

abnormal humerus morphology ( J:211773 )

IMPC - HAR

abnormal radius morphology ( J:211773 )

♂

IMPC - HAR

abnormal ulna morphology ( J:211773 )

♂

IMPC - HAR

abnormal femur morphology ( J:211773 )

IMPC - HAR

abnormal fibula morphology ( J:211773 )

IMPC - HAR

abnormal tibia morphology ( J:211773 )

IMPC - HAR

short tibia ( J:211773 )

IMPC - HAR

abnormal clavicle morphology ( J:211773 )

IMPC - HAR

abnormal pelvic girdle bone morphology ( J:211773 )

♂

IMPC - HAR

abnormal rib morphology ( J:211773 )

IMPC - HAR

abnormal vertebrae morphology ( J:211773 )

♂

IMPC - HAR

increased bone mineral content ( J:211773 )

IMPC - HAR

increased bone mineral density ( J:211773 )

IMPC - HAR

abnormal joint morphology ( J:211773 )

♂

IMPC - HAR

vision/eye

abnormal eyelid morphology ( J:211773 )

IMPC - HAR