Phenotypes associated with this allele

• Allele Symbol: Pkd1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5637215
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pkd1^tm1b(EUCOMM)Hmgu/Pkd1^tm1b(EUCOMM)Hmgu	C57BL/6N-Pkd1^tm1b(EUCOMM)Hmgu/Bay	MGI:6263171
ht2	Pkd1^tm1b(EUCOMM)Hmgu/Pkd1^+	C57BL/6N-Pkd1^tm1b(EUCOMM)Hmgu/Bay	MGI:6263170

Genotype
MGI:6263171

hm1

• Allelic Composition: Pkd1^{tm1b(EUCOMM)Hmgu}/Pkd1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Pkd1^{tm1b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0812_1_A01

Data Sources

IMPC Data for Pkd1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

herniated abdominal wall ( J:211773 )

IMPC - HAR

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

skeleton

abnormal spine curvature ( J:211773 )

IMPC - HAR

Genotype
MGI:6263170

ht2

• Allelic Composition: Pkd1^{tm1b(EUCOMM)Hmgu}/Pkd1⁺
• Genetic Background: C57BL/6N-Pkd1^{tm1b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0812_1_A01

Data Sources

IMPC Data for Pkd1

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

♀

IMPC - HAR

decreased hematocrit ( J:211773 )

IMPC - HAR

increased neutrophil cell number ( J:211773 )

♂

IMPC - HAR

homeostasis/metabolism

decreased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - HAR

decreased circulating total protein level ( J:211773 )

IMPC - HAR

immune system

increased neutrophil cell number ( J:211773 )

♂

IMPC - HAR