All Phenotypes Crx<tm2.1Smgc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Crx^tm2.1Smgc
targeted mutation 2.1, Shiming Chen
MGI:5621025

Summary

2 genotypes

Allelic Composition	Crx^tm2.1Smgc/Crx^tm2.1Smgc
Genetic Background	B6.129X1(CBA)-Crx^tm2.1Smgc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crx^tm2.1Smgc mutation (0 available); any Crx mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Crx^tm1.1Smgc/Crx^tm1.1Smgc, Crx^tm2.1Smgc/Crx^tm2.1Smgc, and Crx^tm1Clc/Crx^tm1Clc mice develop Leber Congenital Amaurosis-like retinopathy

vision/eye

vision/eye phenotype ( J:211011 )

N	• normal lamellar formation of the retina at 14 days of age

abnormal retina layer morphology ( J:211011 )

• no outer segment formation at 14 days through 3 months

• loss of outer layer nuclei starting around 1 month

• only 7-9 rows at 1 month compared to about 12 rows in controls

• 2-3 rows at 3 months

• apoptosis at 21 and 35 days of age

• no light or dark adapted responses

nervous system

• no outer segment formation at 14 days through 3 months

Allelic Composition	Crx^tm2.1Smgc/Crx⁺
Genetic Background	B6.129X1(CBA)-Crx^tm2.1Smgc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crx^tm2.1Smgc mutation (0 available); any Crx mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Crx^tm1.1Smgc/Crx⁺ but not Crx^tm2.1Smgc/Crx⁺ develop dominant retinopathy

vision/eye

vision/eye phenotype ( J:211011 )

N	• normal retinal morphology at all ages • cones are located normally by 1 month of age • opsin expression and distribution normal

• normal overall cone density through 1 year of age despite a modestly reduced density in the central region of the retina

decreased b-wave amplitude ( J:211011 )

• EGR deficits do not appear until 6 months of age

• minor light adapted B wave deficiencies

nervous system

• normal overall cone density through 1 year of age despite a modestly reduced density in the central region of the retina

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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