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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ikzf1tm3.1Mbu
targeted mutation 3.1, Meinrad Busslinger
MGI:5617012
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu
Cd79atm1(cre)Reth/Cd79a+
Rag2tm1Fwa/Rag2tm1Fwa 		involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6 * SJL MGI:5698683
cn2
 		Cd79atm1(cre)Reth/Cd79a+
Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL MGI:5698681
cn3
 		Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu
Il7rtm1.1(icre)Hrr/Il7r+ 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5698686


Genotype
MGI:5698683
cn1
Allelic
Composition		 Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu
Cd79atm1(cre)Reth/Cd79a+
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (29 available)
Ikzf1tm3.1Mbu mutation (0 available); any Ikzf1 mutation (31 available)
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased pro-B cell number ( J:209928 )
• three fold fewer pro-B cells

immune system
decreased pro-B cell number ( J:209928 )
• three fold fewer pro-B cells




Genotype
MGI:5698681
cn2
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (29 available)
Ikzf1tm3.1Mbu mutation (0 available); any Ikzf1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased pro-B cell number ( J:209928 )
• two fold more pro-B cells than in controls
• proliferation of c-Kithi pro-B cells is normal
• c-Kitlo pro-B cells accumulate in the G1-G0 phases of the cell cycle
• cells are smaller with functionally rearranged immunoglobulin mu
• c-Kithi pro-B cells expressing immunoglobulin mu are increased
abnormal B cell number ( J:209928 )
• six fold reduction in total B cell number in bone marrow relative to controls
decreased pre-B cell number ( J:209928 )
• nearly complete loss of pre-B cells

neoplasm
neoplasm ( J:209928 )
N
• evidence of B cell leukemias is not observed during a year of observation

immune system
increased pro-B cell number ( J:209928 )
• two fold more pro-B cells than in controls
• proliferation of c-Kithi pro-B cells is normal
• c-Kitlo pro-B cells accumulate in the G1-G0 phases of the cell cycle
• cells are smaller with functionally rearranged immunoglobulin mu
• c-Kithi pro-B cells expressing immunoglobulin mu are increased
abnormal B cell number ( J:209928 )
• six fold reduction in total B cell number in bone marrow relative to controls
decreased pre-B cell number ( J:209928 )
• nearly complete loss of pre-B cells




Genotype
MGI:5698686
cn3
Allelic
Composition		 Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu
Il7rtm1.1(icre)Hrr/Il7r+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf1tm3.1Mbu mutation (0 available); any Ikzf1 mutation (31 available)
Il7rtm1.1(icre)Hrr mutation (0 available); any Il7r mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm

endocrine/exocrine glands

hematopoietic system

immune system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory