Analysis Tools
hematopoietic system
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• three fold fewer pro-B cells
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immune system
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• three fold fewer pro-B cells
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Allele Symbol Allele Name Allele ID |
Ikzf1tm3.1Mbu targeted mutation 3.1, Meinrad Busslinger MGI:5617012 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• three fold fewer pro-B cells
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• three fold fewer pro-B cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• two fold more pro-B cells than in controls
• proliferation of c-Kithi pro-B cells is normal
• c-Kitlo pro-B cells accumulate in the G1-G0 phases of the cell cycle
• cells are smaller with functionally rearranged immunoglobulin mu
• c-Kithi pro-B cells expressing immunoglobulin mu are increased
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• six fold reduction in total B cell number in bone marrow relative to controls
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• nearly complete loss of pre-B cells
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• two fold more pro-B cells than in controls
• proliferation of c-Kithi pro-B cells is normal
• c-Kitlo pro-B cells accumulate in the G1-G0 phases of the cell cycle
• cells are smaller with functionally rearranged immunoglobulin mu
• c-Kithi pro-B cells expressing immunoglobulin mu are increased
|
|
• six fold reduction in total B cell number in bone marrow relative to controls
|
|
• nearly complete loss of pre-B cells
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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