About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp63tm2.1Aam
targeted mutation 2.1, Alea A Mills
MGI:5616190
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp63tm2.1Aam/Trp63tm2.1Aam Not Specified MGI:5616192
ht2
 		Trp63tm2.1Aam/Trp63tm3Aam involves: 129S7/SvEvBrd MGI:6477405
ht3
 		Trp63tm2.1Aam/Trp63tm3.1Aam involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:6477408
ht4
 		Trp63tm2.1Aam/Trp63tm3.2Aam involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:6477410


Genotype
MGI:5616192
hm1
Allelic
Composition		 Trp63tm2.1Aam/Trp63tm2.1Aam
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2.1Aam mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cellular replicative senescence ( J:158291 )
• Ras-expressing MEFs exhibit enhanced proliferation and compromised oncogene-induced senescence

embryo
embryo phenotype ( J:158291 )
N
• no overt developmental phenotypes are seen

neoplasm
neoplasm ( J:158291 )
N
• no overt tumor phenotypes are seen




Genotype
MGI:6477405
ht2
Allelic
Composition		 Trp63tm2.1Aam/Trp63tm3Aam
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2.1Aam mutation (0 available); any Trp63 mutation (60 available)
Trp63tm3Aam mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:294158 )
• 95% of neonates exhibit cleft palate

digestive/alimentary system
cleft palate ( J:294158 )
• 95% of neonates exhibit cleft palate

growth/size/body
cleft palate ( J:294158 )
• 95% of neonates exhibit cleft palate

integument
thick dermal layer ( J:294158 )
• dermis is thicker in large areas of the skin
abnormal epidermal layer morphology ( J:294158 )
• epidermis is abnormal with the stratum basale and stratum spinosum affected; thickening of Trp63-, K14-, and K10-expressing layers in patches of the epidermis covering the skin surface

limbs/digits/tail
abnormal limb morphology ( J:294158 )
• 100% of neonates exhibit limb defects, ranging from lack of hindlimbs to single ectrodactyly
ectrodactyly ( J:294158 )
• single ectrodactyly in some neonates




Genotype
MGI:6477408
ht3
Allelic
Composition		 Trp63tm2.1Aam/Trp63tm3.1Aam
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2.1Aam mutation (0 available); any Trp63 mutation (60 available)
Trp63tm3.1Aam mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:294158 )
• 70% of neonates exhibit cleft palate

digestive/alimentary system
cleft palate ( J:294158 )
• 70% of neonates exhibit cleft palate

growth/size/body
cleft palate ( J:294158 )
• 70% of neonates exhibit cleft palate

integument
thick dermal layer ( J:294158 )
• dermis is thicker in large areas of the skin
abnormal epidermal layer morphology ( J:294158 )
• epidermis is abnormal with the stratum basale and stratum spinosum affected
thick epidermis ( J:294158 )
• thickening of Trp63-, K14-, and K10-expressing layers in patches of the epidermis covering the skin surface

limbs/digits/tail
limbs/digits/tail phenotype ( J:294158 )
N
• neonates do not exhibit limb defects




Genotype
MGI:6477410
ht4
Allelic
Composition		 Trp63tm2.1Aam/Trp63tm3.2Aam
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2.1Aam mutation (0 available); any Trp63 mutation (60 available)
Trp63tm3.2Aam mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:294158 )
• 100% of neonates exhibit cleft palate

digestive/alimentary system
cleft palate ( J:294158 )
• 100% of neonates exhibit cleft palate

growth/size/body
cleft palate ( J:294158 )
• 100% of neonates exhibit cleft palate

integument
thick epidermis ( J:294158 )
• neonates exhibit an increase in epidermal thickness

limbs/digits/tail
limbs/digits/tail phenotype ( J:294158 )
N
• neonates do not exhibit limb defects




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory