Phenotypes associated with this allele

• Allele Symbol: Thra^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5614615
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thra^tm1b(EUCOMM)Wtsi/Thra^tm1b(EUCOMM)Wtsi	C57BL/6N-Thra^tm1b(EUCOMM)Wtsi/Ics	MGI:5757807
hm2	Thra^tm1b(EUCOMM)Wtsi/Thra^tm1b(EUCOMM)Wtsi	C57BL/6N-Thra^tm1b(EUCOMM)Wtsi/J	MGI:5767825
ht3	Thra^tm1b(EUCOMM)Wtsi/Thra^+	C57BL/6N-Thra^tm1b(EUCOMM)Wtsi/Ics	MGI:5757806
ht4	Thra^tm1b(EUCOMM)Wtsi/Thra^+	C57BL/6N-Thra^tm1b(EUCOMM)Wtsi/J	MGI:6263682

Genotype
MGI:5757807

hm1

• Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0204_5_F02

Data Sources

IMPC Data for Thra

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - ICS

Genotype
MGI:5767825

hm2

• Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/J
• Cell Lines: EPD0204_5_A03

Data Sources

IMPC Data for Thra

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:5757806

ht3

• Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra⁺
• Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0204_5_F02

Data Sources

IMPC Data for Thra

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - ICS

behavior/neurological

abnormal contextual conditioning behavior ( J:211773 )

IMPC - ICS

decreased exploration in new environment ( J:211773 )

IMPC - ICS

decreased startle reflex ( J:211773 )

IMPC - ICS

limb grasping ( J:211773 )

IMPC - ICS

decreased grip strength ( J:211773 )

IMPC - ICS

hyperactivity ( J:211773 )

IMPC - ICS

increased vertical activity ( J:211773 )

IMPC - ICS

cardiovascular system

abnormal heart left ventricle morphology ( J:211773 )

IMPC - ICS

growth/size/body

decreased body length ( J:211773 )

♀

IMPC - ICS

hematopoietic system

increased hematocrit ( J:211773 )

IMPC - ICS

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

IMPC - ICS

increased blood urea nitrogen level ( J:211773 )

IMPC - ICS

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - ICS

improved glucose tolerance ( J:211773 )

♂

IMPC - ICS

limbs/digits/tail

short tibia ( J:211773 )

♂

IMPC - ICS

skeleton

short tibia ( J:211773 )

♂

IMPC - ICS

vision/eye

abnormal retina inner nuclear layer morphology ( J:211773 )

IMPC - ICS

decreased total retina thickness ( J:211773 )

IMPC - ICS

Genotype
MGI:6263682

ht4

• Allelic Composition: Thra^{tm1b(EUCOMM)Wtsi}/Thra⁺
• Genetic Background: C57BL/6N-Thra^{tm1b(EUCOMM)Wtsi}/J
• Cell Lines: EPD0204_5_A03

Data Sources

IMPC Data for Thra

behavior/neurological

increased startle reflex ( J:211773 )

IMPC - JAX

hyperactivity ( J:211773 )

IMPC - JAX

skeleton

abnormal bone structure ( J:211773 )

IMPC - JAX

increased bone mineral content ( J:211773 )

IMPC - JAX

increased bone mineral density ( J:211773 )

IMPC - JAX