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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chn1tm1Ito
targeted mutation 1, Shigeyoshi Itohara
MGI:5614423
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Chn1tm1Ito/Chn1tm1.1Ito
Emx1tm1(cre)Krj/Emx1+ 		involves: 129S2/SvPas * C57BL/6NSlc MGI:5614424
cn2
 		Chn1tm1Ito/Chn1tm1.1Ito
Tg(Slc17a6-icre)1Oki/0 		involves: C57BL/6 * C57BL/6NSlc MGI:5614426


Genotype
MGI:5614424
cn1
Allelic
Composition		 Chn1tm1Ito/Chn1tm1.1Ito
Emx1tm1(cre)Krj/Emx1+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6NSlc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chn1tm1.1Ito mutation (1 available); any Chn1 mutation (44 available)
Chn1tm1Ito mutation (1 available); any Chn1 mutation (44 available)
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:209606 )
N
• unlike in germ line null mice, the gait is similar to that in wild-type mice




Genotype
MGI:5614426
cn2
Allelic
Composition		 Chn1tm1Ito/Chn1tm1.1Ito
Tg(Slc17a6-icre)1Oki/0
Genetic
Background		 involves: C57BL/6 * C57BL/6NSlc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chn1tm1.1Ito mutation (1 available); any Chn1 mutation (44 available)
Chn1tm1Ito mutation (1 available); any Chn1 mutation (44 available)
Tg(Slc17a6-icre)1Oki mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:209606 )
• quadrupedal hopping gait is dominant at all locomotor frequencies
• occasional alternating gait is seen at lower frequencies, occurrence of alternating gait is increased compared to mice heterozygous for Epha4 tm1.1Bzh Epha4tm1.2Bzh and hemizygous for Tg(Slc17a6-icre)1Oki

nervous system
abnormal spinal cord morphology ( J:209606 )
• significantly wider gap between the central canal and the ventral edge of the dorsal funiculus
abnormal nerve fiber response ( J:209606 )
• chemically and electrically stimulated locomotor-like activity in isolated spinal cord preparations induces a synchronous "hopping" locomotor-like activity rather than an alternating locomotor-like activity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory