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Tg(Slc17a6-icre)1Oki
Transgene Detail
Summary
Symbol: Tg(Slc17a6-icre)1Oki
Name: transgene insertion 1, Ole Kiehn
MGI ID: MGI:4881727
Synonyms: BAC-Vglut2::Cre, vGlut2Cre
Transgene: Tg(Slc17a6-icre)1Oki  Location: unknown  
Alliance: Tg(Slc17a6-icre)1Oki page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Slc17a6-icre)1Oki expression driven by 1 gene
 
Mutation detailsRecombineering methods in bacterial cells were used to insert the codon-improved cre open reading frame and FRT-flanked ampicillin resistance gene after the ATG site of the Slc17a6 locus contained in BAC clone RP23-84M15. Insertion of the targeting construct resulting in inactivation of the Slc17a6 gene in the BAC. Flpe recombinase was induced in the bacterial cells and the ampicillin cassette was excised. The purified 201 kb final construct was injected into the pronuclei of C57BL/6 zygotes. Three positive founders were produced. All founders exhibited similar restricted cre expression in the spinal cord, so a line produced from one founder was analyzed further. (J:168055)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc17a6 (mouse)
Summary of all recombinase alleles driven by Slc17a6.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:168055 Borgius L, et al., A transgenic mouse line for molecular genetic analysis of excitatory glutamatergic neurons. Mol Cell Neurosci. 2010 Nov;45(3):245-57
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory