Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Epha4tm1.1Bzh
Name:	Eph receptor A4; targeted mutation 1.1, Binhai Zheng
MGI ID:	MGI:4430285
Synonyms:	EphA4Flox
Gene:	Epha4  Location: Chr1:77343822-77491725 bp, - strand  Genetic Position: Chr1, 39.55 cM, cytoband C1-C5
Alliance:	Epha4tm1.1Bzh page

Germline Transmission:	Earliest citation of germline transmission: J:157159
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Two loxP sites were inserted flanking exon 3. Preceding the floxed exon 3, a reporter/selection cassette (SA-mCFP-Neo) flanked by two Frt sites, containing a splice acceptor, a membrane-targeted cyan fluorescent protein reporter gene and a neo cassette, was inserted. The targeted allele was bred to an FLP deleter mouse to excise the SA-mCFP-Neo cassette, resulting in a floxed exon 3. (J:157159)

Generation of the Epha4tm1Bzh, Epha4tm1.1Bzh and Epha4tm1.2Bzh alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Epha4 Mutation:	66 strains or lines available

Original:	J:157159 Herrmann JE, et al., Generation of an EphA4 conditional allele in mice. Genesis. 2010 Feb;48(2):101-5
All:	18 reference(s)