Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm1.1Bzh mutation
(1 available);
any
Epha4 mutation
(66 available)
|
|
|
behavior/neurological
|
N |
• unlike in germ line null mice, the gait is similar to that in wild-type mice
|
nervous system
|
|
• increased midline re-crossing of axons dorsal to the central canal in both the cervical enlargement and lumbar spinal cord
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm1.1Bzh mutation
(1 available);
any
Epha4 mutation
(66 available)
Epha4tm1.2Bzh mutation
(0 available);
any
Epha4 mutation
(66 available)
Tg(Slc17a6-icre)1Oki mutation
(1 available)
|
|
|
behavior/neurological
|
|
• quadrupedal hopping gait is dominant at all locomotor frequencies
• occasional alternating gait is seen at lower frequencies
|
nervous system
|
|
• increase in axon midline crossing
|
|
|
• significantly wider gap between the central canal and the ventral edge of the dorsal funiculus
|
|
|
• wider and the distance from the ventral edge to the surface of the spinal cord is shorter; however, the total area is not different from controls
|
|
|
• chemically and electrically stimulated locomotor-like activity in isolated spinal cord preparations induces a synchronous "hopping" locomotor-like activity rather than an alternating locomotor-like activity
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm1.1Bzh mutation
(1 available);
any
Epha4 mutation
(66 available)
Epha4tm1.2Bzh mutation
(0 available);
any
Epha4 mutation
(66 available)
Tg(Hoxb8-cre)1403Uze mutation
(0 available)
|
|
|
behavior/neurological
|
|
• dominant hopping hindlimb gait at all frequencies of locomotion with occasional alternating gait at frequencies around and less than 4 Hz
|
nervous system
|
|
• significantly wider gap between the central canal and the ventral edge of the dorsal funiculus
|
|
|
• wider and the distance from the ventral edge to the surface of the spinal cord is shorter; however, the total area is not different from controls
|
nervous system
|
|
• embryos show an increase in the number of abducens nerve bundles following exit from the hindbrain, reductions in both abducens nerve length and diameter at the orbit and larger wandering abducens nerve bundles that exhibit enhanced nerve pausing at the midpoint decision within the abducens fasciculation region
• however, trochlear nerve and first cervical spine projections are normal
|
|
|
• abducens nerve length is reduced and nerve diameter is thinner near the orbit in embryos
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm1.1Bzh mutation
(1 available);
any
Epha4 mutation
(66 available)
Tg(Hlxb9-GFP)1Tmj mutation
(3 available)
Twist2tm1(cre)Dor mutation
(0 available);
any
Twist2 mutation
(10 available)
|
|
|
nervous system
|
|
• the abducens nerve exits the hindbrain with fewer nerve bundles, which initially wander in the mesenchymal area adjacent to the hindbrain exit before completely stalling in the mesenchyme leading to a reduction in abducens length and complete lack of both abducens innervation near the orbit and aberrant tracking with the facial nerve
• however, trochlear nerve and first cervical spine projections are normal
|
Analysis Tools