Analysis Tools
homeostasis/metabolism
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• although total bile acid content in the gallbladder is normal, mice have slightly increased tauro-conjugated cholic acid and less tauro-conjugated muricholic acid
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Allele Symbol Allele Name Allele ID |
Nr5a2tm3.1Sjns targeted mutation 3.1, Kristina Schoonjans MGI:5607404 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• although total bile acid content in the gallbladder is normal, mice have slightly increased tauro-conjugated cholic acid and less tauro-conjugated muricholic acid
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice fed a high-cholesterol diet for 14 weeks develop less atherosclerotic plaques than single Ldlr homozygotes
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• mice fed a regular diet for 14 weeks show only a slight reduction in plasma triglyceride levels compared to single Ldlr homozygotes and are unchanged upon high-cholesterol diet feeding
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• mice exhibit an increase in reverse cholesterol transport
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• mice fed a high-cholesterol diet for 14 weeks show a slight increase in hepatic cholesterol content compared to single Ldlr homozygotes, however hepatic triglyceride content is unchanged
• mice show an increase in expression of genes involved in hepatic cholesterol homeostasis
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• mice fed a high-cholesterol diet for 14 weeks accumulate less cholesterol in their aortas than single Ldlr homozygotes
• however, total plasma cholesterol does not differ from single Ldlr homozygotes on a high-cholesterol diet
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• mice fed a high-cholesterol diet for 14 weeks show a small reduction in the cholesterol content of the low-density lipoprotein subfraction compared to single Ldlr homozygotes
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• mice fed a high-cholesterol diet for 14 weeks show a slight increase in hepatic cholesterol content compared to single Ldlr homozygotes, however hepatic triglyceride content is unchanged
• mice show an increase in expression of genes involved in hepatic cholesterol homeostasis
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• bile flow is increased and biliary cholesterol, bile acids, and phospholipids excretion are enhanced compared to single Ldlr homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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