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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Abcg5tm1.1Hobb
targeted mutation 1.1, Helen H Hobbs
MGI:5605296
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Abcg5tm1.1Hobb/Abcg5tm1.1Hobb
Abcg8tm1.1Hobb/Abcg8tm1.1Hobb
Tg(CAG-cre/Esr1*)5Amc/? 		involves: C57BL/6 * CBA * SJL MGI:5607628
cn2
 		Abcg5tm1.1Hobb/Abcg5tm1.1Hobb
Abcg8tm1.1Hobb/Abcg8tm1.1Hobb
Speer6-ps1Tg(Alb-cre)21Mgn/? 		involves: C57BL/6 * DBA * SJL MGI:5607618
cn3
 		Abcg5tm1.1Hobb/Abcg5tm1.1Hobb
Abcg8tm1.1Hobb/Abcg8tm1.1Hobb
Tg(Vil1-cre)997Gum/? 		involves: C57BL/6 * SJL MGI:5607632


Genotype
MGI:5607628
cn1
Allelic
Composition		 Abcg5tm1.1Hobb/Abcg5tm1.1Hobb
Abcg8tm1.1Hobb/Abcg8tm1.1Hobb
Tg(CAG-cre/Esr1*)5Amc/?
Genetic
Background		 involves: C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg5tm1.1Hobb mutation (1 available); any Abcg5 mutation (47 available)
Abcg8tm1.1Hobb mutation (1 available); any Abcg8 mutation (30 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cellular cholesterol metabolism ( J:215443 )
• levels of sitosterol and campesterol are decreased in gallbladder as compared to controls
decreased cholesterol efflux ( J:215443 )
• decreased amount of cholesterol is excreted into the feces as compared to controls
• decreased amount of cholesterol is excreted into the bile as compared to controls

digestive/alimentary system
increased intestinal phytosterol absorption ( J:215443 )
• fractional absorption of the phytosterols, sitosterol and campesterol, is increased

homeostasis/metabolism
abnormal cellular cholesterol metabolism ( J:215443 )
• levels of sitosterol and campesterol are decreased in gallbladder as compared to controls
decreased cholesterol efflux ( J:215443 )
• decreased amount of cholesterol is excreted into the feces as compared to controls
• decreased amount of cholesterol is excreted into the bile as compared to controls
increased intestinal phytosterol absorption ( J:215443 )
• fractional absorption of the phytosterols, sitosterol and campesterol, is increased
decreased cholesterol level ( J:215443 )
• decreased cholesterol levels in bile, liver and enterocytes as compared to controls
decreased circulating cholesterol level ( J:215443 )
• decreased levels of circulating cholesterol as compared to controls
decreased phytosterol level ( J:215443 )
• levels of sitosterol and campesterol are decreased in gallbladder as compared to controls
increased phytosterol level ( J:215443 )
• increased levels of sitosterol and campesterol in liver as compared to controls
• increased levels of phytosterols in enterocytes
increased circulating phytosterol level ( J:215443 )
• mean plasma levels of sitosterol and campesterol are increased by 95-fold and 14-fold respectively, as compared to controls
• D4-sitostanol levels in plasma are increased as compared to controls
• D7-sitosterol levels in plasma are increased as compared to controls




Genotype
MGI:5607618
cn2
Allelic
Composition		 Abcg5tm1.1Hobb/Abcg5tm1.1Hobb
Abcg8tm1.1Hobb/Abcg8tm1.1Hobb
Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic
Background		 involves: C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg5tm1.1Hobb mutation (1 available); any Abcg5 mutation (47 available)
Abcg8tm1.1Hobb mutation (1 available); any Abcg8 mutation (30 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal cholesterol absorption ( J:215443 )
• rate of clearance of sitosterol from circulation is decreased

homeostasis/metabolism
abnormal cellular cholesterol metabolism ( J:215443 )
• rate of clearance of sitosterol from circulation is decreased
decreased cholesterol efflux ( J:215443 )
• decreased amount of cholesterol is excreted into the feces as compared to controls
• decreased amount of cholesterol is excreted into the bile as compared to controls
abnormal intestinal cholesterol absorption ( J:215443 )
• rate of clearance of sitosterol from circulation is decreased
decreased circulating cholesterol level ( J:215443 )
• decreased levels of circulating cholesterol as compared to controls
increased cholesterol level ( J:215443 )
• levels of cholesterol in the liver are increased as compared to controls
• levels of biliary cholesterol are increased as compared to controls
increased circulating phytosterol level ( J:215443 )
• mean plasma levels of sitosterol and campesterol are increased as compared to controls, but are not as high as mice that carry null alleles for both Abcg5 and Abcg8
decreased phytosterol level ( J:215443 )
• levels of sitosterol and campesterol are decreased in gallbladder as compared to controls
• levels of the plant sterol, stigmasterol, are decreased 6X in the liver as compared to mice that carry null alleles for both Abcg5 and Abcg8

cellular
abnormal cellular cholesterol metabolism ( J:215443 )
• rate of clearance of sitosterol from circulation is decreased
decreased cholesterol efflux ( J:215443 )
• decreased amount of cholesterol is excreted into the feces as compared to controls
• decreased amount of cholesterol is excreted into the bile as compared to controls




Genotype
MGI:5607632
cn3
Allelic
Composition		 Abcg5tm1.1Hobb/Abcg5tm1.1Hobb
Abcg8tm1.1Hobb/Abcg8tm1.1Hobb
Tg(Vil1-cre)997Gum/?
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg5tm1.1Hobb mutation (1 available); any Abcg5 mutation (47 available)
Abcg8tm1.1Hobb mutation (1 available); any Abcg8 mutation (30 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cholesterol efflux ( J:215443 )
• decreased amount of cholesterol is excreted into the feces as compared to controls

digestive/alimentary system
increased intestinal phytosterol absorption ( J:215443 )
• rate of clearance of sitosterol from circulation is decreased
• fractional absorption of the phytosterol, campesterol, is increased

homeostasis/metabolism
decreased cholesterol efflux ( J:215443 )
• decreased amount of cholesterol is excreted into the feces as compared to controls
increased intestinal phytosterol absorption ( J:215443 )
• rate of clearance of sitosterol from circulation is decreased
• fractional absorption of the phytosterol, campesterol, is increased
increased phytosterol level ( J:215443 )
• increased levels of phytosterols in enterocytes
• increased levels of biliary plant sterols (sitosterol and campesterol) as compared to controls
increased circulating phytosterol level ( J:215443 )
• mean plasma levels of sitosterol and campesterol are increased as compared to controls, but are not as high as mice that carry null alleles for both Abcg5 and Abcg8




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04/23/2024
MGI 6.23 		The Jackson Laboratory