Phenotypes associated with this allele

• Allele Symbol: Rtraf^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5585725
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rtraf^tm1b(EUCOMM)Hmgu/Rtraf^tm1b(EUCOMM)Hmgu	C57BL/6N-Rtraf^tm1b(EUCOMM)Hmgu/H	MGI:6263404
ht2	Rtraf^tm1b(EUCOMM)Hmgu/Rtraf^+	C57BL/6N-Rtraf^tm1b(EUCOMM)Hmgu/H	MGI:5797316

Genotype
MGI:6263404

hm1

• Allelic Composition: Rtraf^{tm1b(EUCOMM)Hmgu}/Rtraf^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Rtraf^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0545_3_H06

Data Sources

IMPC Data for Rtraf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - HAR

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:5797316

ht2

• Allelic Composition: Rtraf^{tm1b(EUCOMM)Hmgu}/Rtraf⁺
• Genetic Background: C57BL/6N-Rtraf^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0545_3_H06

Data Sources

IMPC Data for Rtraf

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - HAR

tremors ( J:211773 )

♂

IMPC - HAR

hematopoietic system

increased eosinophil cell number ( J:211773 )

IMPC - HAR

immune system

increased eosinophil cell number ( J:211773 )

IMPC - HAR