Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Ito mutation
(1 available);
any
Emx1 mutation
(34 available)
Ptbp1tm1Nobu mutation
(0 available);
any
Ptbp1 mutation
(34 available)
Ptbp1tm2Nobu mutation
(0 available);
any
Ptbp1 mutation
(34 available)
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nervous system
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• lack of ependymal cilia in the whole dorsal telencephalon, including the anterior and posterior region
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• lack of ependymal cilia in the whole dorsal telencephalon, including the anterior and posterior region
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cellular
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• lack of ependymal cilia in the whole dorsal telencephalon, including the anterior and posterior region
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptbp1tm1Nobu mutation
(0 available);
any
Ptbp1 mutation
(34 available)
Ptbp1tm2Nobu mutation
(0 available);
any
Ptbp1 mutation
(34 available)
Tg(Nes-cre)1Sasa mutation
(0 available)
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mortality/aging
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• all mice die by 10 weeks
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nervous system
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N |
• mice exhibit normal neurogenesis before E14.5
• the overall laminar structure of the cortex is normal
• mice exhibit normal choroid plexus and subcommissural organ
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• lack of ependymal cells on the dorsal wall at P10
• lack of ependymal cell layer is linked to loss of adherens junctions via decrease of neuronal stem cells in the ventricular zone without apoptosis
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• variable severity without stenosis
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• variable severity without stenosis
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• accelerated gliogenesis in the dorsal telencephalon before P2 with reduced GFAP+ cells until P5
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• at E15.5 and E16.5 as determined by marker expression
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• reduced numbers at E18.5 due to precocious differentiation
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• ectopically located basal progenitor cells along the radial axis and at the apical side of the ventricular zone
• periventricular heterotropias at P0 and P10 located at the dorsal wall of lateral ventricles or striato-cortical junction
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craniofacial
cellular
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• at E15.5 and E16.5 as determined by marker expression
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skeleton
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptbp1tm1Nobu mutation
(0 available);
any
Ptbp1 mutation
(34 available)
Ptbp1tm2Nobu mutation
(0 available);
any
Ptbp1 mutation
(34 available)
Tg(Nes-cre/ERT2)#Kag mutation
(0 available)
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nervous system
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N |
• mice treated with tamoxifen at E16.5 exhibit mature ependymal cells on the ventricular wall of the dorsal cortex at P10
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Analysis Tools