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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-Mir184)#Mnpy
transgene insertion, Matthew N Poy
MGI:5585169
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Ins2-rtTA)2Efr/0
Tg(tetO-Mir184)#Mnpy/0 		involves: C57BL/6 * CBA MGI:5585178
cx2
 		Lepob/Lepob
Tg(Ins2-rtTA)2Efr/0
Tg(tetO-Mir184)#Mnpy/0 		involves: C57BL/6 * CBA MGI:5585179


Genotype
MGI:5585178
cx1
Allelic
Composition		 Tg(Ins2-rtTA)2Efr/0
Tg(tetO-Mir184)#Mnpy/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2-rtTA)2Efr mutation (2 available)
Tg(tetO-Mir184)#Mnpy mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased pancreatic beta cell proliferation ( J:210552 )
• in doxycycline-treated mice
decreased pancreatic beta cell mass ( J:210552 )
• in doxycycline-treated mice
decreased pancreatic beta cell number ( J:210552 )
• in doxycycline-treated mice

homeostasis/metabolism
increased circulating glucose level ( J:210552 )
• in doxycycline-treated mice
decreased circulating insulin level ( J:210552 )
• in doxycycline-treated mice
impaired glucose tolerance ( J:210552 )
• in doxycycline-treated mice

cellular
decreased pancreatic beta cell proliferation ( J:210552 )
• in doxycycline-treated mice




Genotype
MGI:5585179
cx2
Allelic
Composition		 Lepob/Lepob
Tg(Ins2-rtTA)2Efr/0
Tg(tetO-Mir184)#Mnpy/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepob mutation (5 available); any Lep mutation (20 available)
Tg(Ins2-rtTA)2Efr mutation (2 available)
Tg(tetO-Mir184)#Mnpy mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating glucose level ( J:210552 )
• in doxycycline-treated mice
decreased circulating insulin level ( J:210552 )
• in doxycycline-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory